Name: Dr. Nopporn Thasana

Office address: R412 / R403B & R404, Laboratory of Medicinal Chemistry
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 25530 8555 (ext. 8962 / 8967)
E-mail: Research Scientist II

Research Interests
– Total synthesis of bioactive natural and natural-like products
– Synthetic methodology (metal-mediated C–X (X = C, N, O) bond formation)
– Natural products chemistry (ferns and fern allies)

Education
1999 – 2003 Ph.D. (Organic Chemistry), Mahidol University, Thailand
1993 – 1996 M.Sc. (Organic Chemistry), Mahidol University, Thailand
1989 – 1992 B.Sc. (Chemistry) with 2nd Class Honors, Ramkamhaeng University, Thailand

Work Experiences
2015 – present Research Scientist II, Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Thailand
2010 – 2015 Research Scientist I, Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Thailand
2009 Visiting Fellow, Nagoya University, Japan
2003 Visiting Fellow, Nagoya University, Japan
2001 Visiting Fellow, Bristol University, United Kingdom
1997 – 2010 Research Scientist, Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Thailand

Awards
2017 ACP Lectureship Award, Asian Core Program (ACP): Cutting-Edge Organic Chemistry in Asia, China
2015 ACP Lectureship Award, Asian Core Program (ACP): Cutting-Edge Organic Chemistry in Asia, Singapore
2011 ACP Lectureship Award, Asian Core Program (ACP): Cutting-Edge Organic Chemistry in Asia, Korea
2011 ACP Lectureship Award, Asian Core Program (ACP): Cutting-Edge Organic Chemistry in Asia, Taiwan
2007 Science and Technology Research Grant, Thailand Toray Science Foundation, Thailand

Publications
– Pongpamorn P, Wan-erlor S, Ruchirawat S, Thasana N. Semi-synthetic Studies of α-Onocerin Derivative for Cytotoxicity. Phytochem. Lett. 2018; 23: 106-115.
– Bag BG, Hasan SN, Pongpamorn P, Thasana N. First Hierarchical Self-assembly of a seco-Triterpenoid α-Onocerin Yielding Supramolecular Architectures: Entrapment and Release of Fluorophores Including an Anticancer Drug. ChemistrySelect 2017; 2: 6650-6657.
– Nealmongkol P, Calmes J, Ruchirawat S, Thasana N. Synthesis of Phenanthridinones using Cu- or Pd-mediated C–N bond formation. Tetrahedron 2017; 73: 735-741.
– Pongpamorn P, Wan-erlor S, Ruchirawat S, Thasana N. Lycoclavatumide and 8β,11α-Dihydroxylycopodine, a New Fawcettimine and Lycopodine-type Alkaloid from Lycopodium clavatum. Tetrahedron 2016; 72: 7065-7069.
– Thiengmag T, Whangsuk W, Chuencharoen S, Thasana N, Mongkolsuk S, Loprasert S. Bacterial Consortium Expressing Surface Displayed, Intra and Extracellular Lipases and Pseudopyronine B for the Degradation of Oil. Int. J. Environ. Sci. Tech. 2016; 13: 2067-2078.
– Nilsu T, Thorroad S, Ruchirawat S, Thasana N. New Lycopodium Alkaloids from Thai and Philippine Huperzia squarrosa. Planta Med. 2016; 82: 1046-1050. Abstract
– Noomnual S, Thasana N, Sungkeeree P, Mongkolsuk S, Loprasert S. Streptanoate. A New Anticancer Butanoate from Streptomyces sp. DC3. J. Antibiotics 2016; 69: 124-127.
– Thorroad S, Worawittayanont P, Khunnawutmanotham N, Chimnoi N, Jumruksa A, Ruchirawat S, Thasana N. Three New Lycopoium Alkaloids from Huperzia carinata and H. squarrosa. Tetrahedron 2014; 70: 8017-8022.
– Isobe M, Murata M, Hanashima S, Nishida A, Loh TP, Abd Rahman N, Thasana N, Chittchang M. JSPS Asian Core Program: 7th & 8th ICCEOCA (Phase II/NICCEOCA-3 &-4), 2nd & 3rd Junior ICCEOCA, and Partly IUPAC Asian Project. Chem. Asian J. 2014; 9: 1689-1696.
– Worayuthakarn R, Boonya-udtayan S, Ruchirawat S, Thasana N. Total Synthesis of Scandione and Calophione A. Eur. J. Org. Chem. 2014; 2496-2507.
– Nealmongkol P, Tangdenpaisal K, Ruchirawat S, Thasana N. Cu(I)-mediated Lactone Formation in Subcritical Water: A Benign Synthesis of Benzopyranones and Urolithins A-C. Tetrahedron 2013; 69: 9277-9283.
– Boonya-udtayan S, Eno M, Ruchirawat S, Mahidol C, Thasana N. Palladium-catalyzed Intramolecular C-H Activation: Synthesis and Biological Activities of Indolobenzazocin-8-ones. Tetrahedron 2012; 68: 10293-10301.
– Worayuthakarn R, Nealmongkol P, Ruchirawat S, Thasana N. Synthesis of Benzoindoloquinolizines via Cu(I)-mediated C-N Bond Formation. Tetrahedron 2012; 68: 2864-2875.
– Wittayalai S, Sathalalai S, Thorroad S, Worawittayanon P, Ruchirawat S, Thasana N. Lycophlegmariols A-D: Cytotoxic Serratene Triterpenoids from the Club Moss Lycopodium phlegmaria L. Phytochemistry 2012; 76: 117-123.
– Worawittayanon P, Ruadree J, Disadee W, Sahakitpichan P, Sitthimonchai S, Thasana N, Ruchirawat S, Kanchanapoom T. Iridoid and Flavone Glycosides from Asystasia salicifolia and Their Antioxidant Activities. Biochem. Syst. Ecol. 2012; 40: 38-42.
– Adachi M, Higuchi K, Thasana N, Yamada H, Nishikawa T. Stereocontrolled Synthesis of an Indole Moiety of Sespendole and Stereochemical Assignment of the Side Chain. Org. Lett. 2012; 14: 114-117.
– Kanintronkul Y, Worayuthakarn R, Thasana N, Winayanuwattikun P, Pattanapanyasat K, Surarit R, Ruchirawat S, Svasti J. Overcoming Multidrug Resistance in Human Lung Cancer with Novel Benzo[a]quinolizin-4-one Chemomodulators. Anticancer Research 2011; 31: 921-927.
– Thipnate P, Chittchang M, Thasana N, Saparpakorn P, Ploypradith P, Hannongbua S. Exploring the Molecular Basis for Selective Cytotoxicity of Lamellarins against Human Hormone-dependent T47D and Hormone-independent MDA-MB-231 Breast Cancer Cells. Monatsh. Chem. 2011; 142: 97-109.
– Boonya-udtayan S, Yotapan N, Woo C, Bruns CJ, Ruchirawat S, Thasana N. Synthesis and Biological Activities of Azalamellarins. Chem. Asian J. 2010; 5: 2113-2123.
– Thasana N, Prapagdee B, Rangkadilok N, Sallabhan R, Lwin Aye S, Ruchirawat S, Loprasert S. Bacillus subtilis SSE4 Produces Subtulene A, a New Lipopeptide Possessing an Unusual C15 Unsaturated Amino acid. FEBS Lett. 2010; 584: 3209-3214.
– Worayuthakarn R, Boonya-udtayan S, Arom-oon E, Ploypradith P, Ruchirawat S, Thasana N. Synthesis of Unsymmetrical Benzil Licoagrodione. J. Org. Chem. 2008; 73: 7432-7435.
– Thasana N, Bjerke-Kroll B, Ruchirawat S. A Facile Synthesis of Telisatin A via Microwave-promoted Annulation and Reformatsky Reaction. Synlett 2008; 505-508.
– Thasana N, Worayuthakarn R, Kradanrat P, Hohn E, Young L, Ruchirawat S. Copper(I)-mediated and Microwave-assisted Caryl-Ocarboxylic Coupling: Synthesis of Benzopyaranones and Isolamellarin Alkaloids. J. Org. Chem. 2007; 72: 9379-9382.
– Worayuthakarn R, Thasana N, Ruchirawat S. Three Distinct Reactions of 3,4-Dihydroisoquinolines with Azlactones: Novel Synthesis of Imidazoloisoquinolin-3-ones, Benzo[a]quinolizin-4-ones, and Benzo[d]azocin-4-ones. Org. Lett. 2006; 8: 5845-5848.
– Thasana N, Pisutjaroenpong S, Ruchirawat S. Two Protocols for the Conversion of Biphenol to Binaphthol: Synthesis of Diospyrol. Synlett 2006; 1080-1084.
– Athikomkulchai S, Prawat H, Thasana N, Ruangrungsi N, Ruchirawat S. COX-1, COX-2 Inhibitors and Antifungal Agents from Croton hutchinsonianus. Chem. Pharm. Bull. 2006; 54: 262-264.
– Sahakitpichan P, Thasana N, Ruchirawat S. Efficient Synthesis of Diospyrol via Suzuki-Miyaura and Modified in situ Cross-coupling. Synthesis 2005; 2934-2938.
– Tempeam A, Thasana N, Pavaro C, Chuakul W, Siripong P, Ruchirawat S. A New Cytotoxic Daphnane Diterpenoid, Rediocide G, from Trigonostermon reidioides. Chem. Pharm. Bull. 2005, 53, 1321-1323.
– Kondo N, Kuse M, Mutarapat T, Thasana N, Isobe M. Novel Synthetic Route of Coelenterazines-2-: Synthesis of Various Dehydrocoelenterazine Analogs. Heterocycles 2005; 65: 843-856.
– Thasana N, Ruchirawat S. Directed Remote Metalation: The Synthesis of Wrightiadione. Synlett 2003; 1037-1039.
– Thasana N, Prachyawarakorn V, Tontoolarug S, Ruchirawat S. Synthesis of Aryl -keto Esters via the Rearrangement of Aryl Cyanohydrin Carbonate Esters. Tetrahedron Lett. 2003; 44: 1019-1021.
– Chuankamnerdkarn M, Sutthivaiyakit S, Thasana N, Pisutjaroenpong S. Prenylated Isoflavones from Derris scandens. Heterocycles 2002; 57: 1901-1906.
– Karig G, Moon M-T, Thasana N, Gallagher T. C-H Activation and Palladium Migration within Biaryls under Heck Reaction Conditions. Org. Lett. 2002; 4: 3115-3118.
– Thasana N, Ruchirawat S. The Application of the Baker-Venkataraman Rearrangement to the Synthesis of Benz[b]indeno[2,1-e]pyran-10,11-dione. Tetrahedron Lett. 2002; 43: 4315-4317.
– Karig G, Thasana N, Gallagher T. Directed Deprotonation-transmetalation of 4-Bromopyridine: Flexible Routes to Substituted Pyridines. Synlett 2002; 808-810.
– Ruchirawat S, Thasana N. The First Synthesis of Wrightiadione. Synth. Commun. 2001; 31: 1765-1769.
– Thasana N, Chuankamnerdkarn M, Ruchirawat S. A New 12a-Hydroxyelliptone from the Stems of Derris malaccensis. Heterocycles 2001; 55: 1121-1125.