Dr. Montakarn Chittchang
Name: Dr. Montakarn Chittchang
54 Kamphaeng Phet 6 Road, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
E-mail: 
Research Scientist I
Research Interests
Current research interests focus on the investigations of biologically-active compounds, especially those with anticancer activities. The scope of ongoing research encompasses mechanism-based biological screenings, structure-activity relationship (SAR) studies, as well as drug development and delivery.
Education
1999 – 2004: Ph.D. (Pharmaceutical Sciences), University of Missouri-Kansas City, USA
1991 – 1996: B.Sc. (Pharmacy) with 1st Class Honors, Chulalongkorn University, Thailand
Work Experiences
2009 – present: Research Scientist I, Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Thailand
2007 – 2016: Lecturer, Chemical Biology Program, Chulabhorn Graduate Institute, Thailand
2005 – 2009: Research Scientist, Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Thailand
2001 – 2004: Student Assistant, Information Services, University of Missouri-Kansas City, USA
2000 – 2004: Graduate Research Assistant, Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, USA
1996 – 1999: Pharmacist, Drug Control Division, Thailand Food and Drug Administration, Thailand
Awards
2008 – 2012: Asian CORE Program (ACP) Lectureship Awards for 1-week visits to Japan (2009), China (2010), Taiwan (2011), and Korea (2013)
Jun 2004: 3rd Prize for Poster Presentation at the 36th Annual Pharmaceutics Graduate Students Research Meeting (PGSRM), Iowa City, IA, USA
2003 – 2004: School of Graduate Studies Distinguished Dissertation Fellowship, School of Graduate Studies, University of Missouri-Kansas City, USA
2002 – 2003: Chancellor’s Interdisciplinary Ph.D. Fellowship, School of Graduate Studies, University of Missouri-Kansas City, USA
2001 – 2002: Dean’s Doctoral Scholar Fellowship, School of Graduate Studies, University of Missouri-Kansas City, USA
1999 – 2001: Chancellor’s Non-Resident (CNR) Award, School of Graduate Studies, University of Missouri-Kansas City, USA
Jul 1996: Gold Medal Award for academic excellence, Chulalongkorn University, Thailand
1996: Senior Project Competition Award from Pharmaceutical Association of Thailand under the Royal Patronage, Thailand
Mar 1996: 2nd Runner-Up Award in the Senior Project Competition, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand
Jun 1995: Award for Academic Excellence, Chulalongkorn University, Thailand
Jun 1995: Award for Academic Excellence, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand
Publications
Research Articles:
– Chittchang M, Theppawong A. An Overview of the Multifaceted Lessons Learned from Marine-Derived Bioactive Lamellarin Natural Products. In: Studies in Natural Products Chemistry (Ed. Atta-ur-Rahman), Elsevier, 2018; Vol. 61: pp. 411-460.
– Theppawong A, Ploypradith P, Chuawong P, Ruchirawat S, Chittchang M. Facile and Divergent Synthesis of Lamellarins and Lactam-containing Derivatives with Improved Drug Likeness and Biological Activities. Chem. Asian J. 2015; 10: 2631-2650.
– Tangdenpaisal K, Worayuthakarn R, Karnkla S, Ploypradith P, Intachote P, Sengsai S, Saimanee B, Ruchirawat S, Chittchang M. Designing New Analogs for Streamlining the Structure of Cytotoxic Lamellarin Natural Products. Chem. Asian J. 2015; 10: 925-937.
– Thipnate P, Chittchang M, Thasana N, Saparpakorn P, Ploypradith P, Hannongbua S. Exploring the Molecular Basis for Selective Cytotoxicity of Lamellarins against Human Hormone-dependent T47D and Hormone-independent MDA-MB-231 Breast Cancer Cells. Monatsh. Chem. 2011; 142: 97-109.
– Chittchang M, Gleeson MP, Ploypradith P, Ruchirawat S. Assessing the Drug-likeness of Lamellarins, a Marine-derived Natural Product Class with Diverse Oncological Activities. Eur. J. Med. Chem. 2010; 45: 2165-2172.
– Chittchang M, Batsomboon P, Ruchirawat S, Ploypradith P. Cytotoxicities and Structure-activity Relationships of Natural and Unnatural Lamellarins toward Cancer Cell Lines. ChemMedChem 2009; 4: 457-465.
– Chittchang M, Mitra AK, Johnston TP. Interplay of Secondary Structure and Charge on the Diffusion of a Polypeptide through Negatively-charged Aqueous Pores. Pharm. Res. 2007; 24: 502-511.
– Salamat-Miller N, Chittchang M, Johnston, TP. The Use of Mucoadhesive Polymers in Buccal Drug Delivery. Adv. Drug Deliv. Rev. 2005; 57: 1666-1691.
– Salamat-Miller N, Chittchang M, Mitra AK, Johnston TP. A Randomly Coiled, High-molecular-weight Polypeptide Exhibits Increased Paracellular Diffusion In Vitro and In Situ Relative to the Highly Ordered Alpha-helix Conformer. Pharm. Res. 2005; 22: 245-254.
– Johnston TP, Kuchimanchi KR, Alur HH, Chittchang M, Mitra AK. Inducing a Change in the Pharmacokinetics and Biodistribution of Poly-L-lysine in Rats by Complexation with Heparin. J. Pharm. Pharmacol. 2003; 55: 1083-1090.
– Salamat-Miller N, Chittchang M, Mitra AK, Johnston TP. Shape Imposed by Secondary Structure of a Polypeptide Affects Its Free Diffusion through Liquid-filled Pores. Int. J. Pharm. 2002; 244: 1-8.
– Chittchang M, Salamat-Miller N, Alur HH, Vander Velde DG, Mitra AK, Johnston TP. Poly(L-lysine) as a Model Drug Macromolecule with Which to Investigate Secondary Structure and Membrane Transport, Part II: Diffusion Studies. J. Pharm. Pharmacol. 2002; 54: 1497-1505.
– Chittchang M, Alur HH, Mitra AK, Johnston TP. Poly(L-lysine) as a Model Drug Macromolecule with Which to Investigate Secondary Structure and Membrane Transport, Part I: Physicochemical and Stability Studies. J. Pharm. Pharmacol. 2002; 54: 315-323.
Scientific Articles:
– Isobe M, Murata M, Hanashima S, Nishida A, Loh TP, Rahman NA, Thasana N, Chittchang M. JSPS Asian Core Program: 7th and 8th ICCEOCA (Phase II/NICCEOCA-3 and -4), 2nd and 3rd Junior ICCEOCA, and Partly IUPAC Asian Project. Chem. Asian J. 2014; 9: 1689–1696.
– Isobe M, Wong HNC, Shing TKM, Huang P-Q, Kanokmedhakul S, Hannongbua S, Chittchang M, Nishida A. JSPS Asian Core Program: Cutting-Edge Organic Chemistry in Asia (Phase II), 14th Asian Chemical Congress, and IUPAC Joint Workshop: Strategic Planning for a New East and Southeast Asian Network for Organic Chemistry. Chem. Asian J. 2012; 7: 1468-1471.
– Nishida A, Uang B-J, Chittchang M, Isobe M. JSPS Asian Core Program: Cutting-Edge Organic Chemistry in Asia and IUPAC Strategic Planning for a New East and Southeast Asian Network for Organic Chemistry. Chem. Asian J. 2011; 6: 1300-1303.
– Ruchirawat S, Chittchang M, Ploypradith P. The Asian CORE Program: Cutting-Edge Organic Chemistry in Asia. ScienceAsia 2007; 33 Suppl 1: 29-31.
Proceedings:
– Pungkham H, Swatdipakdi N, Theerasilp M, Karnkla S, Chittchang M, Ploypradith P, Nasongkla N. PEG-b-PCL and PEG-b-PLA Polymeric Micelles as Nanocarriers for Lamellarin N Delivery. In: Proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS), Boston, MA, USA; 30 Aug – 3 Sep 2011.
