Name: Dr. Poonsakdi Ploypradith

Office address: R413 / R403B, Laboratory of Medicinal Chemistry
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 25530 8555 (ext. 8977 / 8967)
E-mail: Research Scientist II

Research Interests
– Synthetic methodology
– Total synthesis of natural products
– Medicinal chemistry of bioactive compounds

Education
1996 – 1999 Ph.D. (Organic Chemistry), The Johns Hopkins University, U.S.A.
1994 – 1996 M.A. (Organic Chemistry), The Johns Hopkins University, U.S.A.
1990 – 1994 B.A. (Chemistry) with honors, The Johns Hopkins University, U.S.A.

Work Experiences
2015 – present Research Scientist II, Chulabhorn Research Institute, Thailand
2009 – 2015 Research Scientist I, Chulabhorn Research Institute, Thailand
2007 – present Lecturer, Chulabhorn Graduate Institute, Thailand
2000 – 2009 Research Scientist, Chulabhorn Research Institute, Thailand
2000 – 2007 Guest lecturer, King Mongkut’s University of Technology Thonburi, Thailand

Awards
2011 ACP Lectureship to Hong Kong, Asian CORE Program-NRCT
2011 ACP Lectureship to Malaysia, Asian CORE Program-NRCT
2009 ACP Lectureship to Taiwan, Asian CORE Program-NRCT
2009 ACP Lectureship to Singapore, Asian CORE Program-NRCT
2008 ACP Lectureship to China, Asian CORE Program-NRCT
2008 ACP Lectureship to Korea, Asian CORE Program-NRCT
2003 Best Oral Presentation Award (The 1st Conference “New Researchers Meet TRF Senior Research Scholars”), Thailand Research Fund (TRF), Thailand
1995 The Ernest M Marks Award for Excellence in Research and Instruction, The Johns Hopkins University, U.S.A.
1994 – present Phi Beta Kappa National Honor Society, The Johns Hopkins University, U.S.A.
1993 – present Golden Key National Honor Society, The Johns Hopkins University, U.S.A.
1993 – present Alpha Epsilon Delta Premedical Honor Society, The Johns Hopkins University, U.S.A.
1989 – 1994 King’s Scholarship, Office of the Civil Service Commission, Thailand

Selected Publications (2009-present)
– Tangdenpaisal K, Chuayboonsong K, Ruchirawat S, Ploypradith P. A Divergent Strategy for the Diastereoselective Synthesis of the Tricyclic 6,7-Diaryl-tetrahydro-6H-benzo[c]chromene Core via Pt(IV)-catalyzed Cycloaddition of ortho-Quinone Methides and Olefin Ring-closing Metathesis. J. Org. Chem. 2017; 82: 2672-2688.
– Kitisripanya T, Inyai C, Krittanai S, Likhitwitayawuid K, Sritularak B, Ploypradith P, Tanaka H, Morimoto S, Putalun W. Monoclonal Antibody-based Immunoassay for Determination of Oxyresveratrol from Artocarpus lacucha Buch.-Ham. J. Nat. Med. 2017; 71: 523-530.
– Tadtong S, Chatsumpun N, Sritularak B, Jongbunprasert V, Ploypradith P, Likhitwitayawuid K. Effects of Oxyresveratrol and Its Derivatives on Cultured P19-derived Neurons. Trop. J. Pharm. Res. 2016; 15: 2619-2628.
– Yasamut K, Jongcharoenkamol J, Ruchirawat S, Ploypradith P. A Modified Cu(0)-Cu(I)-mediated C_aryl-C_aryl Ullmann Coupling for the Synthesis of Biaryls. Tetrahedron 2016; 72: 5994-6000.
– Chatsumpun N, Chuanasa T, Sritularak B, Lipipun V, Jongbunprasert V, Ruchirawat S, Ploypradith P, Likhitwitayawuid K. Oxyresveratrol: Structural Modification and Evaluation of Biological Activities. Molecules 2016; 21: 489.
– Theppawong A, Ploypradith P, Chuawong P, Ruchirawat S, Chittchang, M. Facile and Divergent Synthesis of Lamellarins and Lactam-containing Derivatives with Improved Drug-likeness and Biological Activities. Chem. Asian J. 2015; 10: accepted.
– Tangdenpaisal K, Worayuthakarn R, Karnkla S, Ploypradith P, Intachote P, Sengsai S, Saimanee B, Ruchirawat S, Chittchang M. Designing New Analogs for Streamlining the Structure of Cytotoxic Lamellarin Natural Products. Chem. Asian J. 2015; 10: 925-937.
– Tangdenpaisal K, Chuayboonsong K, Sukjarean P, Katesampao V, Noiphrom N, Ruchirawat S, Ploypradith P. Synthesis of C4–C5 Cycloalkyl-fused and C6-modified Chromans via ortho-Quinone Methides. Chem. Asian J. 2015; 10: 1050-1064.
– Tangdenpaisal K, Ruchirawat S, Ploypradith P. Synthesis of the Thyroid Hormone Analog GC-1 via Bi(OTf)3-catalyzed Benzylation. Tetrahedron 2014; 70: 6789-6795.
– Sarnpitak P, Trongchit K, Kostenko Y, Sathalalai S, Gleeson MP, Ruchirawat S, Ploypradith P. Synthesis of Substituted 2-Arylindanes from E-(2-Stilbenyl)methanols via Lewis acid-mediated Cyclization and Nucleophililc Transfer from Trialkylsilyl Reagents. J. Org. Chem. 2013; 78: 8281-8296.
– Tangdenpaisal K, Phakhodee W, Ruchirawat S, Ploypradith P. Facile Synthesis of Diarylmethanes via Quinone Methides. Tetrahedron 2013; 69: 933-941.
– Disadee W, Ploypradith P, Aree T, Ruchirawat S. A Novel Approach for the Synthesis of Lophocladines A, B and C1 Analogues. Tetrahedron Lett. 2011; 52: 6142-6144.
– Radomkit S, Sarnpitak P, Tummatorn J, Batsomboon P, Ruchirawat S, Ploypradith P. Pt(IV)- and Au(III)-Catalyzed Generation of o-Quinone Methides and [4+2]-Cycloaddition Reactions. Tetrahedron 2011; 67: 3904-3914.
– Thipnate P, Chittchang M, Thasana N, Saparpakorn P, Ploypradith P, Hannongbua S. Exploring the Molecular Basis for Selective Cytotoxicity of Lamellarins against Human Hormone-dependent T47D and Hormone-independent MDA-MB-231 Breast Cancer Cells. Monatsh. Chem. 2011; 142: 97-109.
– Pungkham H, Swatdipakdi N, Theerasilp M, Chittchang M, Karnkla S, Ploypradith P, Nasongkla N. PEG-b-PCL and PEG-b-PLA Polymeric Micelles as Nanocarriers for Lamellarin N Delivery. IEEE 2011; 3245-3248.
– Chittchang C, Gleeson MP, Ploypradith P, Ruchirawat S. Assessing the Drug-likeness of Lamellarins, a Marine Derived Natural Product Class with Diverse Oncological Activities. Eur. J. Med. Chem. 2010; 45: 2165-2172.
– Tummatorn J, Ruchirawat S, Ploypradith P. A Convergent General Strategy for the Functionalized 2-Aryl Cycloalkyl-fused Chromans: Intramolecular Hetero Diels—Alder (HDA) Reactions of ortho-Quinone Methides (o-QMs). Chem. Eur. J. 2010; 16: 1445-1448.
– Batsomboon P, Phakhodee W, Ruchirawat S, Ploypradith P. Generation of ortho-Quinone Methides by p-TsOH on Silica and Their Hetero-Diels—Alder Reactions with Styrenes. J. Org. Chem. 2009; 74: 4009-4012.
– Tangdenpaisal K, Sualek S, Ruchirawat S, Ploypradith P. Factors Affecting Orthogonality in the Deprotection of 2,4-Di-Protected Aromatic Ethers Employing Solid-Supported Acids. Tetrahedron 2009; 65: 4316-4325.
– Chittchang M, Batsomboon P, Ruchirawat S, Ploypradith P. Cytotoxicities and Structure-Activity Relationships of Natural and Unnatural Lamellarins towards Cancer Cell Lines. ChemMedChem 2009; 4: 457-465.
– Phakhodee W, Ploypradith P, Sahakitpichan P, Ruchirawat S. A New Synthetic Approach towards Isoquinobenzazepinone and Isoindolinobenzazepinone Using Acid-Mediated Cyclisation and Heck Reaction. Tetrahedron 2009; 65: 351-356.