Dr. Lukana Ngiwsara


lukana
Name: Dr. Lukana Ngiwsara

Office address
: : B701C, 7th Floor, Biomedical Science Building
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 25530 8555 (ext. 8356 )
E-mail: lukana 

Research Scientist I

Research Interests
Enzymology, Protein structure and function, Molecular biology,

Education
– B.Sc. (Biochemistry), Chulalongkorn University, Thailand
– M.S. (Biochemistry), Mahidol University, Thailand
– M.S. (Agrobiology), Hokkaido University, Japan
– Ph.D. (Agrobiology), Hokkaido University, Japan

Publications
1.Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Ngiwsara L, Svasti J, Koizumi K. Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-κB/VCAM-1 pathway in human lymphatic endothelial cells. Vasc Med. 2018 Jun;23(3):201-211.
2.Ngiwsara L, Ketudat-Cairns JR, Sawangareetrakul P, Charoenwattanasatien R, Champattanachai V, Kuptanon C, Pangkanon S, Tim-Aroon T, Wattanasirichaigoon D, Svasti J. p.X654R IDUA variant among Thai individuals with intermediate mucopolysaccharidosis type I and its residual activity as demonstrated in COS-7 cells. Ann Hum Genet. 2018 May;82(3):150-157.
3.Subhasitanont P, Chokchaichamnankit D, Chiablaem K, Keeratichamroen S, Ngiwsara L, Paricharttanakul NM, Lirdprapamongkol K, Weeraphan C, Svasti J, Srisomsap C. Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells. Oncol Lett. 2017 Oct;14(4):4361-4371.
4.Ngiwsara L, Rojnueangnit K, Wattanasirichaigoon D, Tim-Aroon T, Sawangareetrakul P, Champattanachai V, Ketudat-Cairns JR, Svasti J. Molecular analysis of the novel IDS allele in a Thai family with mucopolysaccharidosis type II: The c.928C>T (p.Gln310*) transcript is sensitive to nonsense-mediated mRNA decay. Exp Ther Med. 2017 Jun;13(6):2989-2996.
5.Rukkijakan T, Ngiwsara L, Lirdprapamongkol K, Svasti J, Phetrak N, Chuawong P. A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells. Bioorg Med Chem Lett. 2016 May 1;26(9):2119-23.
6. Lang W, Sirisansaneeyakul S, Martins LO, Ngiwsara L, Sakairi N, Pathom-aree W, Okuyama M, Mori H, Kimura A. Biodecolorization of a food azo dye by the deep sea Dermacoccus abyssi MT1.1(T) strain from the Mariana Trench. J Environ Manage. 2014 Jan; 132:155-64.
7. Lang W, Sirisansaneeyakul S, Ngiwsara L, Mendes S, Martins LO, Okuyama M, Kimura A. Characterization of a new oxygen-insensitive azoreductase from Brevibacillus laterosporus TISTR1911: toward dye decolorization using a packed-bed metal affinity reactor. Bioresour Technol. 2013 Dec; 150:298-306.
8. Ngiwsara L, Iwai G, Tagami T, Sato N, Nakai H, Okuyama M, Mori H, and Kimura A. Amino acids in conserved region II are crucial to substrate specificity, reaction velocity, and regioselectivity in the transglucosylation of honeybee GH-13 -glucosidases. Biosci. Biotechnol. Biochem. 2012
9. Chimnoi N, Pisutjaroenpong S, Ngiwsara L, Dechtrirut D, Chokchaichamnankit D, Khunnawutmanotham N, Mahidol C, Techasakul S. Labdane diterpenes from the rhizomes of Hedychium coronarium. Nat Prod Res. 2008; 22(14):1249-56.
10. Keeratichamroen S, Cairns JR, Wattanasirichaigoon D, Wasant P, Ngiwsara L, Suwannarat P, Pangkanon S, Kuptanon J, Tanpaiboon P, Rujirawat T, Liammongkolkul S, Svasti J. Molecular analysis of the iduronate-2-sulfatase gene in Thai patients with Hunter syndrome. J Inherit Metab Dis. 2008 Dec; 31 Suppl 2: S303-11. Epub 2008 May 20.
11. Suwannarat P, Keeratichamroen S, Wattanasirichaigoon D, Ngiwsara L, Cairns JR, Svasti J, Visudtibhan A, Pangkanon S. Molecular characterization of type 3 (neuronopathic) Gaucher disease in Thai patients. Blood Cells Mol Dis. 2007 Nov-Dec; 39(3): 348-52. Epub 2007 Aug 8.
12. Comparison of membrane-associated proteins in human cholangiocarcinoma and hepatocellular carcinoma cell lines. Srisomsap C, Subhasitanont P, Sawangareetrakul P, Chokchaichamnankit D, Ngiwsara L, Chiablaem K, Svasti J. Proteomics Clin Appl. 2007 Jan;1(1):89-106.
13. Wattanasirichaigoon D, Svasti J, Cairns JR, Tangnararatchakit K, Visudtibhan A, Keeratichamroen S, Ngiwsara L, Khowsathit P, Onkoksoong T, Lekskul A, Mongkolsiri D, Jariengprasert C, Thawil C, Ruencharoen S. Clinical and molecular characterization of an extended family with Fabry disease. J Med Assoc Thai. 2006 Sep; 89(9): 1528-35.
14. Ketudat Cairns JR, Keeratichamroen S, Sukcharoen S, Champattanachai V, Ngiwsara L, Lirdprapamongkol K, Liammongkolkul S, Srisomsap C, Surarit R, Wasant P, Svasti J. The molecular basis of mucopolysaccharidosis type I in two Thai patients. Southeast Asian J Trop Med Public Health. 2005 Sep; 36(5): 1308-12.
15. Svasti J, Srisomsap C, Subhasitanont P, Keeratichamroen S, Chokchaichamnankit D, Ngiwsara L, Chimnoi N, Pisutjaroenpong S, Techasakul S, Chen ST. Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis. Proteomics. 2005 Nov; 5(17): 4504-9.
16. Ngiwsara L, Srisomsap C, Winichagoon P, Fucharoen S, Sae-Ngow B, Svasti J. Hb Kurosaki [alpha7(A5)Lys→Glu (AAG→GAG)]: an alpha2-globin gene mutation found in Thailand. Hemoglobin. 2005;29(2): 155-9.
17. Ngiwsara L, Srisomsap C, Winichagoon P, Fucharoen S, Svasti J. Two cases of compound heterozygosity for Hb Hekinan [alpha27(B8)Glu→Asp (alpha1)] and alpha-thalassemia in Thailand. Hemoglobin. 2004 May; 28(2): 145-50.
18. Imjongjirak, C., Ngiwsara L., Pramual, C., Insuan, S., Para-or, K., Klinbunga, S. and Sittipraneed, S. Development of a simple and rapid method for typing population origins of the honey bee (Apis cerana) in Thailand. J. Apicul. Res. 2004; 43: 17-20
19. Ngiwsara L, Srisomsap C, Winichagoon P, Fucharoen S, Svasti J. Hb Kodaira II [beta146(HC3)His→Gln] detected in Thailand. Hemoglobin. 2003 Feb; 27(1): 37-9

 

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