Name: Dr. Nuchanart RangkadilokOffice address: Laboratory of Pharmacology, 4 ^th Floor, Biomedical Science Building
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 2553 8555 (ext. 8281 )
E-mail:

Position: Research Scientist I

Research Interests
• Plant physiology, Phytochemical analysis, Pharmaceutics and standardization of Thai traditional medicines
• Pharmacokinetic of phytochemical compounds in human, Metal analysis in food and its biotransformation

Education
1999-2002 Ph.D. (School of Agriculture and Food Systems) The Melbourne School of Land and Environment The University of Melbourne, Australia
1989-1993 Bachelor of Pharmacy (second class honors) Faculty of Pharmacy Chiang Mai University, Chiang Mai, Thailand

Area of expertise
• Extraction and isolation of phytochemical compounds from medicinal plants
• Liquid-liquid and solid phase extraction
• TLC, HPLC/GC analysis of phytochemical compounds

Publications
– Arsenic speciation and accumulation in selected organs after oral administration of rice extracts in Wistar rats.
Lewchalermvong K,Rangkadilok N, Nookabkaew S, Suriyo T, Satayavivad J.
J Agric Food Chem. 2018, 66: 3199-3209.

– The role of nutrition in influencing mechanisms involved in environmentally mediated diseases.
Hennig B, Petriello MC, Gamble MV, Surh Y-J, Kresty LA, Frank N, Rangkadilok N, Ruchirawat M, Suk WA.
Rev Environ Health. 2018; 33: 87-97

– Clinical parameters following multiple oral dose administration of a standardized Andrographis paniculata capsule in healthy Thai subjects.
Suriyo T, Pholphana N, Ungtrakul T, Rangkadilok N, Panomvana D, Thiantanawat A, Pongpun W, Satayavivad J.
Planta Med. 2017;83: 778–789.

– Hijiki and sodium arsenic stimulate growth of human colorectal adenocarcinoma cells through ERK1/2 activation.
Cholpraipimorat W, Suriyo T, Rangkadilok N, Nookabkaew S, Satayavivad J.
Food Chem Toxicol 2017; 110: 33-41.

– Andrographis paniculata: dissolution investigation and pharmacokinetic studies of four major active diterpeniods after multiple oral dose.
Pholphana N, Panomvana D, Rangkadilok N, Suriyo T, Puranajoti P, Ungtrakul T, Pongpun W, Thaeopattha S, Songvut P, Satayavivad J.
J Ethnopharmacol 194 p513-21 (2016)

– Concentrations of trace elements in organic fertilizers and animal manures and feeds and cadmium contamination in herbal tea (Gynostemma pentaphyllum Makino).
Nookabkaew S, Rangkadilok N, Prachoom N., Satayavivad J.
J Agric and Food Chem 64 p3119-26 (2016)

– Longan (Dimocarpus longan Lour.) inhibits liposaccharide-stimulated nitric oxide production in macrophages by suppressing NF-B and AP-1 signaling pathways.
Kunworarah N, Rankadilok N, Suriyo T, Thiantanawat A, Satayavivad J.
J Ethnopharmacol 179 p156-61 (2016)

– A simple and sensitive LC-MS/MS method for determination of four major active diterpenoids from Andrographis paniculata in human plasma and its application to a pilot study.
Pholphana N, Panomvana D, Rangkadilok N, Suriyo T, Ungtrakul T, Pongpun W, Thaeopattha S, Satayavivad J.
Planta Med 82 p113-20 (2016)

– Developmental changes of sinigrin and glucoraphanin in three Brassica species (Brassica nigra, Brassica juncea and Brassica oleracea var. italica). Scientia Horticulturae.
Rangkadilok, N., Nicolas, M.E., Bennett, R.N, Premier, R.R., Eagling, D.R., Taylor, P.W.J. (2002).  , 96(1-4), 11-26. (https://www.sciencedirect.com/science/article/pii/S0304423802001188)

– Rangkadilok, N., Nicolas, M.E., Bennett, R.N, Premier, R.R., Eagling, D.R., Taylor, P.W.J. (2002). Determination of sinigrin and glucoraphanin in Brassica species using a simple extraction method combined with ion-pair HPLC analysis. Scientia Horticulturae, 96(1-4), 27-41. (https://www.sciencedirect.com/science/article/pii/S030442380200119X)

– Rangkadilok, N., Tomkins, B., Nicolas, M.E., Bennett, R.N, Premier, R.R., Eagling, D.R., Taylor, P.W.J. (2002). The effect of post-harvest and packaging treatments on glucoraphanin concentration in broccoli (Brassica oleracea var. italica). Journal of Agricultural and Food Chemistry, 50(25), 7386-7391. (https://www.ncbi.nlm.nih.gov/pubmed/12452663)

– Rangkadilok, N., Nicolas, M.E., Bennett, R.N, Eagling, D.R., Premier, R.R., Taylor, P.W.J. (2004). The effect of sulphur fertilizer on glucoraphanin levels in broccoli (Brassica oleracea var. italica) at different growth stages. Journal of Agricultural and Food Chemistry, 52(9), 2632-2639. (https://www.ncbi.nlm.nih.gov/pubmed/15113170)

– Pholphana, N., Rangkadilok, N., Thongnest, S., Ruchirawat, S., Ruchirawat, M., Satayavivad, J. (2004). Determination and variation of three active diterpenoids in Andrographis paniculata (Burm.f.) Nees. Phytochemical Analysis, 15 (6), 365-371.
(https://www.ncbi.nlm.nih.gov/pubmed/15595451)

– Rangkadilok, N., Worasuttayangkurn, L., Bennett, R.N., Satayavivad, J.  (2005). Identification and quantification of polyphenolic compounds in longan (Euphoria longana Lam.) fruit. Journal of Agricultural and Food Chemistry, 53(5), 1387-1392.
(https://www.ncbi.nlm.nih.gov/pubmed/15740011)

– Nookabkaew, S., Rangkadilok, N., Satayavivad, J. (2006). Determination of trace elements in herbal tea products and their infusions consumed in Thailand. Journal of Agricultural and Food Chemistry, 54(18), 6939-6944.
(https://www.ncbi.nlm.nih.gov/pubmed/16939361)

– Thisoda, P., Rangkadilok, N., Pholphana, N., Worasuttayangkurn, L., Ruchirawat, S., Satayavivad, J. (2006). Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation. European Journal of Pharmacology, 553(1-3), 39-45.
(https://www.ncbi.nlm.nih.gov/pubmed/17081514)

– Rangkadilok, N., Sitthimonchai, S., Worasuttayangkurn, L., Mahidol, C., Ruchirawat, M, Satayavivad, J. (2007). Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract. Food and Chemical Toxicology, 45(2), 328-336.
https://www.ncbi.nlm.nih.gov/pubmed/17049706)

– Yoopan, N., Thisoda, P., Rangkadilok, N., Sahasitiwat, S., Pholphana, N., Ruchirawat, S., Satayavivad, J. (2007). Cardiovascular effects of 14-deoxy-11,12-didehydroandrographolide and Andrographis paniculata extracts. Planta Medica, 73, 503-511.
(https://www.ncbi.nlm.nih.gov/pubmed/17650544)

– Fuangthong, M., Sallabhan, R., Atichartpongkul, S., Rangkadilok, N., Sriprang, R., Satayavivad, J., Mongkolsuk, S. (2008). The omlA gene is involved in multidrug resistance and its expression is inhibited by coumarins in Xanthomonas campestris pv. phaseoli. Archives of Microbiology. 189(3), 211-218. (https://www.ncbi.nlm.nih.gov/pubmed/179573530)

– Suntararuks, S., Yoopan, N., Rangkadilok, N., Worasuttayangkurn, L., Nookabkaew, S., Satayavivad, J. (2008). Immunomodulatory effects of cadmium and Gynostemma pentaphyllum herbal tea on rat spenocyte proliferation. Journal of Agricultural and Food Chemistry. 56(19), 9305-9311. (https://www.ncbi.nlm.nih.gov/pubmed/18795782)

– Rangsriwong, P., Rangkadilok, N., Shotipruk, A. (2008). Subcritical water extraction of polyphenolic compounds from Terminalia chebula Fruits. Chiang Mai Journal of Science. 35(1), 103-108. (https://it.science.cmu.ac.th/ejournal/journalDetail.php?journal_id=346)

– Rangsriwong, P., Rangkadilok, N., Satayavivad, J., Goto, M., Shotipruk, A. (2009). Subcritical water extraction of polyphenolic compounds from Terminalia chebula Retz. fruits. Separation and Purification Technology. 66(1), 51-56.
(https://www.sciencedirect.com/science/article/pii/S1383586608004838)

– Thasana, N., Prapagdee, B., Rangkadilok, N., Sallabhan, R., Aye. S.L., Ruchirawat, S., Loprasert, S. (2010). Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated beta-amino acid.  FEBS Letters. 584(14), 3209-3214.
(https://www.ncbi.nlm.nih.gov/pubmed/20541548)

– Rangkadilok, N., Pholphana, N., Mahidol, C., Wongyai, W., Saengsooksree, K., Nookabkaew, S., Satayavivad, J. (2010). Variation of sesamin, sesamolin and tocopherols in sesame (Sesamum indicum L.) seeds and oil products in Thailand. Food Chemistry. 122, 724-730. (https://www.sciencedirect.com/science/article/pii/S0308814610003183)

– Pianjing, P., Thiantanawat, A., Rangkadilok, N., Watcharasit, P., Mahidol, C., Satayavivad, J. (2011). Estrogenic activities of sesame lignans and their metabolites on human breast cancer cells. Journal of Agricultural and Food Chemistry. 59(1), 212-221.
(https://www.ncbi.nlm.nih.gov/pubmed/21141889)

– Wichitsranoi, J., Weerapreeyakul, N., Boonsiri, P., Settasatian, C., Settasatian, N., Komanasin, N., Sirijaichingkul, S., Teerajetgul, Y., Rangkadilok, N., Leelayuwat, N. (2011). Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans. Nutrition Journal (Open Assess). 10:82, https://www.nutritionj.com/content/10/1/82 (https://www.ncbi.nlm.nih.gov/pubmed/21827664)

– Rangkadilok, N., Tongchusak, S., Boonhok, R., Chaiyaroj, S.C., Junyaprasert, V.B., Buajeeb, W., Akanimanee, J., Raksasuk, T., Suddhasthira, T., Satayavivad, J. (2012). In vitro antifungal activities of longan (Dimocarpus longan Lour.) seed extract. Fitoterapia. 83(3), 545-553. (https://www.ncbi.nlm.nih.gov/pubmed/22245574)

– Worasuttayangkurn, L., Watcharasit, P., Rangkadilok, N., Suntararuks, S., Khamkong, P., Satayavivad, J. (2012). Safety evaluation of longan seed extract: Acute and repeated oral administration. Food and Chemical Toxicology. 50(11), 3949-3955.
(https://www.ncbi.nlm.nih.gov/pubmed/229028050)

– Nookabkaew, S., Rangkadilok, N., Akib, C.A., Tuntiwigit, N., Saehun, J., Satayavivad, J. (2013). Evaluation of trace elements in selected foods and dietary intake by young children in Thailand. Food Additives and Contaminants: Part B Surveillance. 6 (1), 55-67.
(https://www.ncbi.nlm.nih.gov/pubmed/24786626)

– Pholphana, N., Rangkadilok, N., Saehun, J., Ritruechai, S., Satayavivad, J. (2013). Changes in the contents of four active diterpenoids at different growth stages in Andrographis paniculata (Burm.f.) Nees (Chuanxinlian). Chinese Medicine. 8(1): 2.
(https://www.ncbi.nlm.nih.gov/pubmed/23320627)

– Thongprakaisang, S., Thiantanawat, A., Rangkadilok, N., Suriyo, T., Satayavivad, J. (2013). Glyphosate induces human breast cancer cells growth via estrogen receptors. Food and Chemical Toxicology 59:129-136. (https://www.ncbi.nlm.nih.gov/pubmed/23756170)

– Nookabkaew, S., Rangkadilok, N., Mahidol, M., Promsuk, G., Satayavivad, J. (2013). Determination of arsenic species in rice from Thailand and other Asian countries using simple extraction and HPLC-ICP-MS analysis. Journal of Agricultural and Food Chemistry. 61(28): 6991-6998. (https://www.ncbi.nlm.nih.gov/pubmed/23859827)

–  Suriyo, T., Pholphana, N., Rangkadilok, N., Thiantanawat, A., Watcharasit, P., Satayavivad, J. (2014). Andrographis paniculata extracts and major constituent diterpenoids inhibit growth of intrahepatic cholangiocarcinoma cells by inducing cell cycle arrest and apoptosis. (2014). Planta Medica. 80(7): 533-543.
(https://www.ncbi.nlm.nih.gov/pubmed/24782229)

–  Rangkadilok, N., Siripriwon, P., Nookabkaew, S., Suriyo, T., Satayavivad, J. (2014). Arsenic, cadmium, and manganese levels in shellfish from Map Ta Phut, an Industrial area in Thailand, and the potential toxic effects on human cells. Archives of Environmental Contamination and Toxicology. 2015; 68:169-180.
(https://www.ncbi.nlm.nih.gov/pubmed/24986306)

Conference papers:

– Rangkadilok, N., Premier, R., Eagling, D., Taylor, P.W.J. (1998). Distribution and genetics of anticancer phytochemicals in Brassica crops. Proceedings of the 1998 ASBMB/ASPP Combined Conference, Adelaid. (poster)

– Rangkadilok, N., Premier, R., Eagling, D., Taylor, P.W.J. (1998). Distribution of anticancer phytochemicals in Brassica crops. Proceedings of the 5th Annual Scientific Symposium of the Joint Centre for Crop Improvement. The University of Melbourne, Melbourne, Victoria, p 41. (oral presentation)

– Rangkadilok, N., Premier, R., Eagling, D., Taylor, P.W.J. (1999). Distribution of anticancer phytochemicals in Brassica crops. Proceedings of The Melbourne Thai Forum Seminar. The University of Melbourne, Parkville, Victoria, p 59. (oral presentation)

– Rangkadilok, N., Premier, R., Eagling, D., Nicolas, M., Taylor, P.W.J. (1999). Anticancer compounds in Brassica vegetables and their distribution during plant development. Proceedings of the Combined Conference of the ASBMB/ANZSCDB/ASPP (ComBio 99). Gold Coast, Queensland. (poster)

– Rangkadilok, N., Premier, R., Eagling, D., Nicolas, M., Taylor, P.W.J. (1999). Sinigrin and Glucoraphanin : Anticancer glucosinolates in Brassica vegetables. Proceedings of the 6th Annual Scientific Symposium of the Joint Centre for Crop Improvement. Longerenong, Victoria., p 33. (oral presentation)

– Rangkadilok, N., Premier, R., Eagling, D., Nicolas, M., Taylor, P.  (2000). Changes of glucoraphanin concentration in broccoli. Proceedings of the 7th Annual Scientific Symposium of the Joint Centre for Crop Improvement.  Rutherglen, Victoria, p 16. (oral presentation)

– Rangkadilok, N., Premier, R., Eagling, D., Nicolas, M., Taylor, P. (2000). Detection and distribution of glucoraphanin, the precursor of anticancer phytochemical sulforaphane, in Brassica species. Proceedings of the Asia Pacific Conference on Plant Tissue Culture and Agribiotechnology.  The National University of Singapore, Singapore. (oral presentation)

– Rangkadilok, N., Premier, R., Eagling, D., Nicolas, M., Taylor, P. (2000). Anticancer glucosinolate in broccoli.  Proceedings of the International Conference Tropical Agriculture Technology for Better Health and Environment. Kasetsart University, Nakhon Pathom, Thailand, p O-10. (oral presentation)

– Suntararuks, S., Charoenying, S., Rangkadilok, N., Satayavivad, J. (2005). The effects
of irradiation on the active compounds in Curcuma longa.  The 31st Congress on Science and
Technology of Thailand. Suranaree University of Technology, Nakhon Ratchima, Thailand. Oct.18-20. Abstract book (N0002) p.337.

– Nookabkaew, S., Rangkadilok, N., Satayavivad, J. (2005). Evaluation of trace elements in medicinal plants from Thai markets.  The 31st Congress on Science and Technology of Thailand. Suranaree University of Technology, Nakhon Ratchima, Thailand. Oct.18-20. Abstract book (N0018) p.342.

– Rangkadilok, N., Worasuttayangkurn, L., Akanimanee, J., Khamkong, P., Satayavivad, J. (2005). Polyphenolic compounds in longan fruit and their pharmacological activities.  The 31st Congress on Science and Technology of Thailand. Suranaree University of Technology, Nakhon Ratchima, Thailand.  Oct.18-20. Abstract book (N0017) p.342.

– Pholphana, N., Rangkadilok, N., Thongnest, S., Ruchirawat, S., Ruchirawat, M., Satayavivad, J. (2005). Determination and variation of three active diterpenoids in Andrographis paniculata (Burm. f.) Nees. The 31st Congress on Science and Technology of Thailand. Suranaree University of Technology, Nakhon Ratchima, Thailand. Oct.18-20. Abstract book (N0019) p.342-343.

– Nookabkaew, S., Rangkadilok, N., Satayavivad, J. (2006). The element concentrations in Gynostemma pentaphyllum Makino and its herbal tea products. The 2nd Asia-Pacific Winter Conference on Plasma Spectrochemistry. Bangkok Thailand. Nov. 27-Dec. 2. Abstract WP03, p. 126.

– Yoopan, N., Nookabkaew, S., Rangkadilok, N., Satayavivad, J. (2006). Effects of routes and exposure times of cadmium on its accumulation in blood and organs of rats. The 2nd Asia-Pacific Winter Conference on Plasma Spectrochemistry. Bangkok Thailand. Nov. 27-Dec. 2. Abstract WP12, p. 133.