Name: Dr. Piyajit Watcharasit

Office address: Laboratory of Pharmacology, 4 ^th Floor, Biomedical Science Building
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 2553 8555 (ext. 8274 )
E-mail:  

Position: Research Scientist II

Research Interests
Neurodegenerative diseases, cell signalings

Education
Ph.D. (Pharmacology) University of Alabama at Birmingham, Birmingham, Alabama, USA

Awards
Ph.D. Thesis award (Honorably mentioned) 2003 from National Research Council of Thailand

Publications

•Sodium arsenite exposure impairs B cell proliferation and enhances vascular inflammation in Plasmodium berghei mouse model
Suntararuks S, Worasuttayangkurn L, Akanimanee J, Suriyo T, Nookabkaew S, ,Srisamut N, Visitnonthachai D, Watcharasit P, Satayavivad J.
Environ Toxicol Pharm. 2019; 66: 7-13.

•Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors
Tanjak P, Thiantanawat A, Watcharasit P, Satayavivad J.
Int J Oncol. 2018; 53(1): 177-188.

• Arsenic impairs insulin signaling in differentiated neuroblastoma SH-SY5Y cells.
Niyomchan A, Visitnonthachai D, Suntararuks S, Ngamsiri P, Watcharasit P, Satayavivad J.
NeuroToxicology 2018;66: 22-31.

• Paraquat induces extrinsic pathway of apoptosis in A549 cells by induction of DR5 and repression of anti-apoptotic proteins, DDX3 and GSK3 expression.
Hathaichoti S, Visitnonthachai D, Ngamsiri P, Niyomchan A, Tsogtbayar O, Wisessaowapak C, Watcharasit P, Satayavivad J.
Toxicol in Vitro. 2017;42: 123-129

• Perfluorinated chemicals, PFOS and PFOA, enhance the estrogenic effects of 17 β –estradiol in T47D human breast cancer cells.
Sonthithai, P., Suriyo, T., Thiantanawat, A., Watcharasit, P., Ruchirawat, M., Satayavivad, J.
J Applied Toxicol 36 p790-801 (2016)

• Sodium arsenite inhibited genomic estrogen signaling but induced pERα (ser118) via MAPK pathway in breast cancer cells.
Nakareangrit W, Thiantanawat A, Visitnonthachai D, Watcharasit P, Satayavivad J.
Environ Tox 31 p1133-46 (2016)

•Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway.
Suriyo T, Tachachartvanich P, Visitnonthachai D, Watcharasit P, Satayavivad J.
Toxicology. 338: 117-29.(2015)

•Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway.
Amonyingcharoen, S., Suriyo, T., Thiantanawat, A., Watcharasit, P., Satayavivad, J.
Int J Oncol. 2015; 46:2317-26.

•Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway.
Niyomchan, A., Watcharasit, P., Visitnonthachai, D., Homkajorn, B., Thiantanawat, A., Satayavivad, J.
Toxicol Lett. 2015, 236(3):138-44.

• Muscarinic receptor activation protects against paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Sangsuwannukul T, Visitnonthachai D, Watcharasit P, Satayavivad J.
Thai J Tox. 2015; 29(1-2):48-56.

• Andrographis paniculata extracts and major constituent diterpenoids inhibit growth of intrahepatic cholangiocarcinoma cells by inducing cell cycle arrest and apoptosis.
Suriyo T, Pholphana N, Rangkadilok N, Thiantanawat A, Watcharasit P, Satayavivad J.
Planta Med. 2014; 80(7):533-43.

• Glycogen synthase kinase-3 (GSK3) controls deoxyglucose-induced mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells.
Ngamsiri P, Watcharasit P, Satayavivad J.
Mitochondrion. 2014; 14(1):54-63.

• β-catenin involvement in arsenite-induced VEGF expression in neuroblastoma SH-SY5Y cells.
Watcharasit P, Suntararuks S, Visitnonthachai D, Thiantanawat A, Satayavivad J.
Environ Toxicol. 2014; 29:672-8.

• Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells.
Ngok-ngam P, Watcharasit P, Thiantanawat A, Satayavivad J.
Cell Mol Biol Lett. 2013; 18:58-74.

• Safety evaluation of longan seed extract: Acute and repeated oral administration.
Worasuttayangkurn L, Watcharasit P, Rangkadilok N, Suntararuks S, Khamkong P, Satayavivad J.
Food Chem Toxicol. 2012; 50:3949-55.

• Arsenite promotes apoptosis and dysfunction in microvascular endothelial cells via an alteration of intracellular calcium homeostasis.
Suriyo T, Watcharasit P, Thiantanawat A, Satayavivad J.
Toxicol In Vitro. 2012; 26:386-95.

• Low arsenite concentrations induce cell proliferation via activation of VEGF signaling in human neuroblastoma SH-SY5Y cells.
Watcharasit P, Visitnonthachai D, Suntararuks S, Thiantanawat A, Satayavivad J.
Environ Toxicol Pharmacol. 2012; 33:53-9.

• Estrogenic activities of sesame lignans and their metabolites on human breast cancer cells.
Pianjing P, Thiantanawat A, Rangkadilok N, Watcharasit P, Mahidol C, Satayavivad J.
J Agric Food Chem. 2011; 59:212-21.

• Acrylonitrile induced apoptosis via oxidative stress in neuroblastoma SH-SY5Y cell.
Watcharasit P, Suntararuks S, Visitnonthachai D, Thiantanawat A, Satayavivad J.
J Appl Toxicol. 2012; 30:649-55.

• Attenuation of eNOS expression in cadmium-induced hypertensive rats.
Yoopan N, Watcharasit P, Wongsawatkul O, Piyachaturawat P, Satayavivad J.
Toxicol Lett. 2008; 176:157-61.

• GSK 3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption.
Watcharasit P, Thiantanawat A, Satayavivad J.
J Appl Toxicol. 2008; 28:466-74.

• Determination of levels of Mn, As, and other metals in water, sediment, and biota from Phayao Lake, Northern Thailand, and assessment of dietary exposure.
Tupwongse V, Parkpian P, Watcharasit P, Satayavivad J.
J Environ Sci Health A. 2007; 42:1029-41.

• Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells.
Chantara N, Watcharasit P, Thiantanawat A, Satayavivad J.
J Appl Toxicol. 2006; 26:517-23.

• Effects of permethrin on muscarinic cholinergic receptors in mouse striatum.
Prutipanlai S, Chongthammakun S, Piyachaturawat P, Wongsawatkul O, Watcharasit P, Satayavivad S.
International proceeding: New trends in Alzheimer and Parkinson related disorders: ADPD 2005:131-6.

• The pharmacodynamic study of a potent new antimalarial (MC1).
Satayavivad J, Watcharasit P, Khamkong P, Tuntawiroon J, Pavaro C, Ruchirawat S.
Acta Tropica. 2004; 89:343-9.

• Glycogen synthase kinase-3β (GSK3β) binds to and promotes the actions of p53.
Watcharasit P, Bijur GN, Song L, Zhu J, Chen X, Jope RS.
J Biol Chem. 2003; 278:48872-9.

• Watcharasit P, Bijur GN, Song L, Zhu J, Chen X, Jope RS.
Glycogen synthase kinase-3 (GSK3) binds to and promotes the actions of p53.
J Biol Chem. 2003; 278(49):48872-9.

• Watcharasit P, Bijur GN, Zmijewski JW, Song L, Zmijewska A, Chen X, Johnson GVW, Jope RS.
Direct, activating interaction between glycogen synthase kinase-3 and p53 after DNA damage.
Proc Natl Acad Sci USA. 2002; 99(12):7951-5.

• Microsample preparation by dielectrophoresis: isolation of malaria.
Gascoyne P, Mahidol C, Ruchirawat M, Satayavivad J, Watcharasit P, Becker F.
Lab On a Chip. 2002; 2(2):70-5.

• Src family kinase involvement in muscarinic receptor-induced tyrosine phosphorylation in differentiated SH-SY5Y cells.
Watcharasit P, Tucholski J, Jope RS.
Neurochemical Research. 2001; 26(7):809-16.

• Alterations of central muscarinic functions during subchronic exposure to acrylonitrile in rats.
Satayavivad J, Thiantanawat A, Tuntawiroon J, Watcharasit P, Ruchirawat M.
Res Comm Biol Psycho Psych. 1998; 23(1&2):29-42.