Name: Nitirat Chimnoi

Office address: R304A, 3rd Floor, Chemistry Research Building
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 25530 8555 (ext. 8947, 8951)
E-mail:

Research Scientist I

Research Interests
1. Essential Oils analysis using Retention Indices(RI) and GC-MS
2. Development of extraction methods for identification of volatile compounds from Thai Flowers
3. Study in isolation and biological activities of bioactive components from Thai plants focusing on antimicrobial, antioxidant, chemoprevention and cytotoxicity
4. Antimicrobial of natural product compounds and their synergistic effects
5. Acetylcholinesterase inhibition-drug designEducation
– M. Sc. (Analytical Chemistry ) Chiangmai University, Chiangmai, Thailand, May, 2000, in the Thesis topic of Development of a cleanup methods for determination of Polychlorinated Biphenyls in selected samples Percentage Score : 100 %
– B.Sc. (Chemistry) Kasetsart University, Bangkok, Thailand , May-1993 with Second Class HonorWork Experiences
1. Join the training course in Magnetic Sector Mass Spectrometer , Finnigan MAT Gm.BH., Bremen, Germany, in 1995
2. Join the training course in maintenance of GC-MS, Agilent Co. Ltd., Texas, U.S.A., in 2002
3. Experiences in using GC and HPLC with most common detectors
4. Experiences in using FAB and EI magnetic sector mass spectrometer
5. Experiences in using GC-MS in both ion trap and quadrupole mass spectrometer
6. Experiences in using LC-MS system ( TOF, Q-TOF, Ion Trap and triple quadrupole MS)
7. Exactmass Measurement in TOF-MS
8. Manual Peptide sequencing from MS-MS spectra
9. Natural product chemistry and simple organic synthesis chemistry
10. Enzymatic assayAwards
–

Publications

–Srinroch C.; Sahakitpichan P.; Chimnoi N.; Ruchirawat S.; Kanchanapoom T. Flavonol triglycosides from Magnolia utilis. Phytochemistry Letters, 2019, 29, 57-60.

–Srinroch C.; Sahakitpichan P.; Techasakul S.; Chimnoi N,; Ruchirawat S.; Kanchanapoom T. 2-Aminobenzoyl and megastigmane glycosides from Wrightia antidysenterica. Phytochemistry Letters, 2019, 29, 61-64.

–Srinroch C.; Sahakitpichan.; Chimnoi N.; Ruchirawat S.; Kanchanapoom T. Neolignan and monoterpene glycosides from Magnolia henryi. Phytochemistry Letters, 2019, 29, 94-97.

-Khunnawutmanotham, N.; Laongthipparos, C.; Saparpakorn, P.; Chimnoi, N.; Techasakul, S. Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase. Beilstein J Org Chem. 14, 2018, 2545-52.

– Chimnoi, N.; Reuk-ngam, N.; Chuysinuan, P.; Khlaychan, P.; Khunnawutmanotham, N.; Chokchaichamnankit, D.; Thamniyom, W.; Klayraung, S.; Mahidol, C.; Techasakul, S. Characterization of essential oil from Ocimum gratissimum leaves: Antibacterial and mode of action against selected gastroenteritis pathogens, Microbial Pathogenesis, 118, 2018, 290-300.

– Sahakitpichan, P.; Chadmuk, P.; Chimnoi, N.; Namsa-aid, A.; Ruchirawat, S.; Kanchanapoom, T., 2-Carboxy-dihydrostilbene and flavan glycosides from Desmodium heterocarpon, Phytochemistry Letters, 19, 2017, 94-97.

– Sahakitpichan, P.; Disadee, W.; Buntawong, R.; Chimnoi, N.; Ruchirawat, S.; Kanchanapoom, T. A furan-2-carbonyl C-glucoside and an alkyl glucoside from the parasitic plant, Dendrophthoe pentandra, Phytochemistry Letters, 21, 2017, 90-93.

– Sahakitpichan, P.; Chimnoi, N.; Wongbundit, S.; Vorasingha, A.; Ruchirawat, S.; Kanchanapoom, T., Phenylethanoid glycosides from the leaves of Magnolia hodgsonii, Phytochemistry Letters, 21, 2017, 269-272.

– Khunnawutmanotham, N.; Sahakitpichan, P.; Chimnoi, N.; Techasakul, S.; Efficient One-Pot Synthesis of Tetrahydronaphtho[2,1-f]isoquinolines by Using Domino Pictet–Spengler/Friedel–Crafts- Type Reactions, European Journal of Organic Chemistry, 43, 2017, 6434-40.

– Chuysinuan, P.,Chimnoi, N. Pattani, L., Khlaychan, P., Nooeaid, P., and Techasakul, S.; Poly(lactic acid) (PLA) electrospun fibers containing rice extract: Release characteristics and their antioxidant activity (Conference Paper), Key Engineering Materials, 757, 2017, 83-87. (11th Pure and Applied Chemistry International Conference, PACCON 2017; Bangkok; Thailand; 2 February 2017 through 3 February 2017; Code 204019).

– Boonsombat, J.; Mahidol, C.; Chawengrum, P.; Reuk-Ngam, N., Chimnoi, N.; Techasakul, S.; Ruchirawat, S.; Thongnest, S. Roscotanes and Roscoranes: Oxygenated Abietane and Pimarane diterpenoids from Kaempferia roscoeana. Phytochemistry, 2017, 143, 36–44.

– Khunnawutmanotham, N.; Chimnoi, N.; Saparpakorn, P.; Techasakul, S. Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives. Bioorg. Chem., 2016, 65, 137-145.

– Sahakitpichan, P.; Chimnoi, N.; Namsa-Aid, A.; Panyadee, A.; Ruchirawat, S.; Kanchanapoom, T. Colchicinoid glucosides from seedless pods of Thai origin Gloriosa superba, Phytochem. Lett., 2016, 16, 299-302.

– Makarasen, A.; Reuk-ngam, N.; Chuysinuan, P.; Aonsri, C.; Isobe, M.; Techasakul, S., In vitro antimicrobial activity of cereulide and valinomycin compare with cyclic D, L-α-peptides and their enhanced effect. Int. J. Pharm. Biol. Sci., 2015, 6(1), 77-85.

– Sahakitpichan, P.; Tanpatanan, W.; Chimnoi, N., Ruchirawat, S.; Kanchanapoom T. Glucosides of phenylpropanoic acid derivatives and coumarins from Micromelum minutum. Phytochem. Lett., 2015, 14, 12-16.

– Khunnawutmanotham, N.; Sahakitpichan, P.; Chimnoi, N.; Techasakul, S., Divergent Total Syntheses to Azafluor­anthene and Dehydroaporphine Alkaloids. Eur. J. Org. Chem., 2015, 28, 6324-6332.

– Thorroad, S.; Worawittayanont, P.; Khunnawutmanotham, N.; Chimnoi, N.; Jumruksa, A.; Ruchirawat, S.; Thasana, N. Three new Lycopodium alkaloids from Huperzia carinata and Huperzia squarrosa, Tetrahedron, 70(43), 2014, 8017-8022.

– Reuk-Ngam, N., Chimnoi, N., Khunnawutmanotham, N. and Techasakul, S., Antimicrobial activity of coronarin D and its synergistic potential with antibiotics, Bio Med Res. Inter., 2014, 2014, Article ID 581985.

– Sahakitpichan, P., Chadmuk, P., Disadee, W., Chimnoi, N., Ruchirawat, S. and Kanchanapoom, T., New trans- and cis-p-coumaroyl flavonol tetraglycosides from the leaves of Mitragyna rotundifolia, Phytochemistry Letters, 8(1), 2014, 65-68.

– Kumarn, S., Chimnoi, N. and Ruchirawat, S., Synthesis of integerrimide A by an on-resin tandem Fmoc-deprotection-macrocyclisation approach Org. Biomol. Chem., 11(44), 2013, 7760-7767.

– Chimnoi, N., Khunnawutmanotham, N., Feungfuloy, P., Chatrewongwan, K. and Techasakul, S., Facile isolation and purification of thailandine, a biologically active oxoaporphine alkaloid, from Stephania venosa leaves using ion-pair liquid-liquid extraction, Res. J. Med. Plant, 7(1), 2013, 68-76.

– Sahakitpichan, P. Mahidol, C., Disadee, W., Chimnoi, N., Ruchirawat, S. and Kanchanapoom, T., Glucopyranosyloxybenzyl derivatives of (R)-2-benzylmalic acid and (R)-eucomic acid, and an aromatic glucoside from the pseudobulbs of Grammatophyllum speciosum, Tetrahedron, 69, 2013, 1031-1037.

– Khunnawutmanotham, N., Chimnoi, N., Champathong, W., Lerdsirisuk, P., Khotmora, T. and Techasakul, S., Coronarin D conjugated to methylene homologues of chlorambucil: synthesis and evaluation of their cytotoxicity J. Chem. Res., 36, 2012, 374-378.

– Kaomongkolgit, R., Jamdee, K., Wongnoi, S., Chimnoi, N. and Techasakul, S., Antifungal activity of coronarin D against Candida Albicans, Oral Surg. Oral Med. Oral Pathol., 114, 2012, 61-66.

– Sutthivaiyakit, S. Seeka, C., Kritwinyu, T., Pisutchareonpong, S., and Chimnoi, N., 19-nor-11-Oxooleanan-12-ene and 18,19-seco-19-oxours- 11,13(18)-diene triterpenes from Diospyros decandra bark, J. Nat. Prod., 53, 2012, 1713-1716.

– Chokchaichamnankit, D., Kongjinda, V., Khunnawutmanotham, N., Chimnoi, N., Pisutcharoenpong, S. and Techasakul, S., Prenylated flavonoids from the leaves of Derris malaccensis and their cytotoxicity, Nat. Prod. Comm., 6, 2011, 1103-1106.

– Makarasen, A., Sirithana, W., Mogkhuntod, S., Khunnawutmanotham, N., Chimnoi, N. and Techasakul, S., Cytotoxic and Antimicrobial Activities of Aporphine Alkaloids Isolated from Stephania venosa (Blume) Spreng. Planta Med. 77, 2011, 1519-1524.

– Duangthongyou, T., Makarasen, A., Techasakul, S., Chimnoi, N. and Siripaisarnpipat, S., (-)-Crebanine, Acta Cryst., 67, 2011, o402.

– Chuysinuan, P., Chimnoi, N., Techasakul, S. and Supaphol, P., Gallic Acid-Loaded Electrospun Poly(L-Lactic Acid) Fiber Mats and their Release Characteristic, Macromolecular Chemistry and Physics, 210, 2009, 814-822.

– Khunnawutmanotham, N., Chimnoi, N., Thitithanyanont, A., Saparpakorn, P., Choowongkomon, K., Pungpo, P., Hannongbua, S. and Techasakul, S., Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity, Beilstein J. Org. Chem., 22, 2009, 36.

– Chimnoi, N., Sarasuk, C., Khunnawutmanotham, N., Intachote, P., Seangsai, S., Saimanee, B., Pisutjaroenpong, S. Mahidol, C. and Techasakul, S., Phytochemical reinvestigation of labdane-type diterpenes and their cytotoxicity from the rhizomes of Hedychium coronarium, Phytochemistry Letters, 2, 2009, 184-187.

– Chimnoi, N., Pisutjaroenpong, S., Ngiwsara, L., Dechtrirut, D., Chokchaichamnankit, D., Khunnawutmanotham, N., Mahidol, C. and Techasakul, S., Labdane diterpenes from the rhizomes of Hedychium coronarium., Nat. Prod. Res., 22, 2008, 249-256.

– Changtam, C., Sukcharoen, O., Yingyongnarongkul, B.E., Chimnoi, N. and Suksamrarn, A., Functional group-mediated biotransformation by Curvularia lunata NRRL 2178: synthesis of 3-dehydro-2-deoxy-ecdysteroids from the 3-hydroxy-2- mesyloxy analogues, Tetrahedron, 64 , 2008, 2626- 2633.

– Khunnawutmanotham, N., Chimnoi, N., Saparpakorn, P., Pungpo, P.,
Louisirirotchanakul, S., Hannongbua, S., and Techasakul, S., Novel 2- chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase, Molecule, 20, 2007, 218-230.

– Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N. and Suksamrarn, A., Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana, Chemical & Pharmaceutical Bulletin, 54, 2006, 301-305.

– Svasti, J., Srisomsap, C. , Subhasitanont, P., Keeratichamroen, S., Chokchaichamnankit, D. , Ngiwsara, L., Chimnoi, N., Pisutjaroenpong, S., Techasakul, S. and Chen, S.T., Proteomic profiling of Cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis, Proteomics, 5, 2005, 4504-4509.

– Yingyongnarongkul, B.E., Kumpun, S. and Chimnoi, N., C-25 epimeric 26- haloponasterone A:synthesis,absolute configuration and moulting activity, Steroids,70, 2005,636-644.

– Phommart, S., Suthivaiyakit, P., Chimnoi, N., Ruchirawat, S. and Suthivaiyakit, S., Constituents of the leaves of Macaranga tanarius, J. Nat. Prod., 68, 2005, 927-930.

– Mahidol, C., Chimnoi, N., Chokchaichamnankit, D. and Techasakul, S., Identification of volatile constituents in Artabotrys hexapetalus flowers using simple headspace solvent-trapping technique in combination with gas chromatography-mass spectrometry and retention indices, Acta Hortic., 2005, 43-50.

– Homvisasevongsa, S., Chuaynugul, A., Chimnoi, N. and Suksamrarna, A., Stereoselective synthesis and moulting activity of 2,3-diepi-20-hydroxyecdysone and 2,3-diepi-5α-20-hydroxyecdysone, Tetrahedron, 60, 2004, 3433

– Suksamrarn, S., Suwannapoch, N., Phakhodee, W., Thanuhiranlert, J., Ratananukul, P., Chimnoi, N. and Suksamrarn, A., Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana, Chem. Pharm. Bull., 51(7), 2003, 857-859.

– Suksamrarn, A., Pattanaprateep, P., Tanachatchairatana, T., Haritakun, W., Yingyongnarongkul, B. and Chimnoi, N. , Chemical Modifications at the 22-hydroxyl group of Ecdysteroids : Alternative Structural Requirements for high Moulting Activity, Insect Biochem Mol Biol. , 32, 2002, 193-197.