This research project aims to study risk factors for the development of liver cancer and cholangiocarcinoma, cancers prevalent in Thailand, focusing on environmental risk factors from exposure to carcinogenic compounds from the environment, food and lifestyles, as well as genetic risk factors in populations living in areas with high incidence of these diseases. The study has also looked at molecular mechanisms by which carcinogenic compounds found in the area can cause changes in cell cultures related to liver cancer and cholangiocarcinoma. Research results will lead to identification of important risk factors and development of more targeted policy measures for prevention and early detection of liver cancer and cholangiocarcinoma.