Office address: Chemical Carcinogenesis Laboratory, Biomedical Building

54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand

Tel: +66 25530 8555 (ext. 8253)

E-mail:

Research Experience (Specialties):  Signal transduction, Molecular cell biology

Education

1994-1997 B.Sc. (Chemistry), Suan Dusit Rajabhat University, Bangkok, Thailand

1999-2002 M.Sc. (Pharmaceutical Chemistry), Mahidol University, Bangkok, Thailand.

2002-2005 Ph.D. (Pharmaceutical Science), University of Toyama, Japan.

Awards 

2002-2005 Monbukagakusho Scholarship

2006-2007 Toyama New Industry Organization Grants, Japan

2009 Poster award at The 10th National Cancer Conference, Bangkok, Thailand

Work Activities
1998 Researcher, Department of Pharmacognosy, Faculty of pharmacy, Mahidol
University, Thailand

2006-2008 Postdoctoral Fellow, Division of Pathogenic Biochemistry,
Department of Bioscience, Institute of Natural Medicine, University of Toyama, Japan

2008-present Researcher, Chemical Carcinogenesis laboratory,
Chulabhorn Research Institute
Publications

Nishimura M, Shin MS, Singhirunnusorn P, Suzuki S, Kawanishi M, Koizumi K, Saiki I, Sakurai H : TAK1-Mediated Serine/Threonine Phosphorylation of EGFR via ERK/p38: NF-kB-Independent Survival Pathways in TNF-α Signaling. Mol. Cell. Biol. 29: 5529-39, 2009.

Shin MS, Singhirunnusorn P, Sugishima Y, Nishimura M, Suzuki S, Koizumi K, Saiki I, Sakurai H : Cross interference with TNF-a-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1. Biochimica et Biophysica Acta. 1793:1156-64, 2009.

Singhirunnusorn P, Ueno Y, Matsuo M, Suzuki S, Saiki I, Sakurai H : Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-alpha through the TAK1-p38 signaling pathway. J Biol Chem. 282: 12698-706, 2007.

Singhirunnusorn P, Suzuki S, Kawasaki N, Saiki I, and Sakurai H : Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-b-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J. Biol. Chem. 280: 7359-7368, 2005.

Suzuki S, Singhirunnusorn P, Mori A, Yamaoka S, Kitajima I, Saiki I, and Sakurai H : Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB. J Biol Chem. 282: 25177-81, 2007.

Choo MK, Kawasaki N, Singhirunnusorn P, Koizumi K, Sato S, Akira S, Saiki I and Sakurai H : Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade. Mol Cancer Ther. 5: 2970-6, 2006.

Suzuki S, Singhirunnusorn P, Nakano H, Doi T, Saiki I, and Sakurai H : Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2. FEBS Lett. 580: 3257-62, 2006.

Sakurai H, Singhirunnusorn P, Shimotabira E, Suzuki S, Chino A, Koizumi K, and Saiki I : TAK1-mediated transcriptional activation of CD28-responsive element and AP-1 site within the IL-2 promoter in Jurkat T cells. FEBS Lett. 579: 6641-6646, 2005.

Lirdprapamongkol K, Sakurai H, Kawasaki N, Choo MK, Saitoh Y, Aozuka Y,

Singhirunnusorn P, Ruchirawat S, Svasti J, and Saiki I : Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci. 25: 57-65. 2005