Name: Phannee SawangareetrakulOffice address: Laboratory of Biochemistry 7th Floor, Biomedical Science Building
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 25530 8555 (ext. 8355 )
E-mail:

Research Scientist I

Research Interests
Protein and enzyme, Cancer biomarker, Human genetic disease

Education
– B.Sc. (Medical Technology), Mahidol University, Bangkok, THAILAND
– M.Sc. (Biochemistry), Mahidol University, Bangkok, THAILAND

Publications

1. Ngiwsara L, Sawangareetrakul P, Wattanasirichaigoon D, Tim-Aroon T, Dejkhamron P, Champattanachai V, Ketudat-Cairns JR, Svasti J. Effects of gentamicin inducing readthrough premature stop Codons: A study of alpha-L-iduronidase nonsense variants in COS-7 Cells. Biochem Biophys Res Commun. 2022 Oct 27;636(Pt 1):147-154. doi: 10.1016/j.bbrc.2022.10.081.
2. Gorantla JN, Maniganda S, Pengthaisong S, Ngiwsara L, Sawangareetrakul P, Chokchaisiri S, Kittakoop P, Svasti J, Ketudat Cairns JR. Chemoenzymatic and Protecting-Group-Free Synthesis of 1,4-Substituted 1,2,3-Triazole-α-d-glucosides with Potent Inhibitory Activity toward Lysosomal α-Glucosidase. ACS Omega. 2021 Sep 22;6(39):25710-25719. doi: 10.1021/acsomega.1c03928.
3. Sawangareetrakul P, Ngiwsara L, Champattanachai V, Chokchaichamnankit D, Saharat K, Ketudat Cairns JR, Srisomsap C, Khwanraj K, Dharmasaroja P, Pulkes T, Svasti J. Aberrant proteins expressed in skin fibroblasts of Parkinson’s disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes. Biomed Rep. 2021 Apr;14(4):36. doi: 10.3892/br.2021.1412. Epub 2021 Feb 17.
4. Ngiwsara L, Vatanavicharn N, Sawangareetrakul P, Liammongkolkul S, Ratanarak P, Boonyawat B, Srisomsap C, Champattanachai V, Ketudat-Cairns J, Wasant P, Svasti J. Molecular characterization of Thai patients with phenylalanine hydroxylase deficiency and in vitro functional study of two novel PAH variants. Mol Biol Rep. 2021 Mar;48(3):2063-2070. doi: 10.1007/s11033-021-06163-w.
5. Kantaputra PN, Dejkhamron P, Tongsima S, Ngamphiw C, Intachai W, Ngiwsara L, Sawangareetrakul P, Svasti J, Olsen B, Cairns JRK, Bumroongkit K. Juberg-Hayward syndrome and Roberts syndrome are allelic, caused by mutations in ESCO2. Arch Oral Biol. 2020 Nov;119:104918. doi: 10.1016/j.archoralbio.2020.104918.
6. Ngiwsara L, Wattanasirichaigoon D, Tim-Aroon T, Rojnueangnit K, Noojaroen S, Khongkraparn A, Sawangareetrakul P, Ketudat-Cairns JR, Charoenwattanasatien R, Champattanachai V, Kuptanon C, Pangkanon S, Svasti J. Clinical course, mutations and its functional characteristics of infantile-onset Pompe disease in Thailand. BMC Med Genet. 2019 Sep 11;20(1):156. doi: 10.1186/s12881-019-0878-8.
7. Ngiwsara L, Ketudat-Cairns JR, Sawangareetrakul P, Charoenwattanasatien R, Champattanachai V, Kuptanon C, Pangkanon S, Tim-Aroon T, Wattanasirichaigoon D, Svasti J. p.X654R IDUA variant among Thai individuals with intermediate mucopolysaccharidosis type I and its residual activity as demonstrated in COS-7 cells. Ann Hum Genet. 2018 May;82(3):150-157. doi: 10.1111/ahg.12236.
8. Ngiwsara L, Rojnueangnit K, Wattanasirichaigoon D, Tim-Aroon T, Sawangareetrakul P, Champattanachai V, Ketudat-Cairns JR, Svasti J. Molecular analysis of the novel <i>IDS</i> allele in a Thai family with mucopolysaccharidosis type II: The c.928C>T (p.Gln310*) transcript is sensitive to nonsense-mediated mRNA decay. Exp Ther Med. 2017 Jun;13(6):2989-2996. doi: 10.3892/etm.2017.4303. Epub 2017 Apr 5.
9. Buncherd H, Roseboom W, Chokchaichamnankit D, Sawangareetrakul P, Phongdara A, Srisomsap C, de Jong L, Svasti J. β-Elimination coupled with strong cation- exchange chromatography for phosphopeptide analysis. Rapid Commun Mass Spectrom. 2016 Jul 30;30(14):1695-1704. doi: 10.1002/rcm.7606.
10. Dejkhamron P, Wejapikul K, Unachak K, Sawangareetrakul P, Tanpaiboon P, Wattanasirichaigoon D. Isolated methylmalonic acidemia with unusual presentation mimicking diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2016 Mar;29(3):373-8. doi: 10.1515/jpem-2015-0228.
11. Sawangareetrakul P, Ketudat Cairns JR, Vatanavicharn N, Liammongkolkul S, Wasant P, Svasti J, Champattanachai V. Analysis of Novel Mutations and Methylmalonyl-CoA Mutase Levels in Thai Patients with Isolated Methylmalonic Acidemia. Biochem Genet. 2015 Dec;53(11-12):310-8. doi:
10.1007/s10528-015-9694-9. Epub 2015 Sep 14.
12. Tit-Oon P, Chokchaichamnankit D, Khongmanee A, Sawangareetrakul P, Svasti J, Srisomsap C. Comparative secretome analysis of cholangiocarcinoma cell line in three-dimensional culture. Int J Oncol. 2014 Nov;45(5):2108-16. doi: 10.3892/ijo.2014.2636. Epub 2014 Sep 3.
13. Charoenwattanasatien R, Cairns JR, Keeratichamroen S, Sawangareetrakul P, Tanpaiboon P, Wattanasirichaigoon D, Pangkanon S, Svasti J, Champattanachai V. Decreasing activity and altered protein processing of human iduronate-2-sulfatase mutations demonstrated by expression in COS7 cells. Biochem Genet. 2012 Dec;50(11-12):990-7. doi: 10.1007/s10528-012-9538-9.
14. Vatanavicharn N, Champattanachai V, Liammongkolkul S, Sawangareetrakul P, Keeratichamroen S, Ketudat Cairns JR, Srisomsap C, Sathienkijkanchai A, Shotelersuk V, Kamolsilp M, Wattanasirichaigoon D, Svasti J, Wasant P. Clinical and molecular findings in Thai patients with isolated methylmalonic acidemia. Mol Genet Metab. 2012 Aug;106(4):424-9. doi: 10.1016/j.ymgme.2012.05.012.
15. Srisomsap C, Sawangareetrakul P, Subhasitanont P, Chokchaichamnankit D, Chiablaem K, Bhudhisawasdi V, Wongkham S, Svasti J. Proteomic studies of cholangiocarcinoma and hepatocellular carcinoma cell secretomes. J Biomed Biotechnol. 2010;2010:437143. doi: 10.1155/2010/437143. Epub 2009 Dec 27.
16. Sawangareetrakul P, Srisomsap C, Chokchaichamnankit D, Svasti J. Galectin-3 expression in human papillary thyroid carcinoma. Cancer Genomics Proteomics. 2008 Mar-Apr;5(2):117-22.
17. Keeratichamroen S, Cairns JR, Sawangareetrakul P, Liammongkolkul S, Champattanachai V, Srisomsap C, Kamolsilp M, Wasant P, Svasti J. Novel mutations found in two genes of thai patients with isolated methylmalonic acidemia. Biochem Genet. 2007 Jun;45(5-6):421-30. doi: 10.1007/s10528-007-9085-y. Epub 2007 Apr 5.
18. Srisomsap C, Subhasitanont P, Sawangareetrakul P, Chokchaichamnankit D, Ngiwsara L, Chiablaem K, Svasti J. Comparison of membrane-associated proteins in human cholangiocarcinoma and hepatocellular carcinoma cell lines. Proteomics Clin Appl. 2007 Jan;1(1):89-106. doi: 10.1002/prca.200600168. Epub 2006 Dec 5.
19. Wasant P, Vatanavicharn N, Srisomsap C, Sawangareetrakul P, Liammongkolkul S, Svasti J. Retrospective study of patients with suspected inborn errors of metabolism at Siriraj Hospital, Bangkok, Thailand (1997-2001). J Med Assoc Thai. 2005 Jun;88(6):746-53.
20. Srisomsap C, Sawangareetrakul P, Subhasitanont P, Panichakul T, Keeratichamroen S, Lirdprapamongkol K, Chokchaichamnankit D, Sirisinha S, Svasti J. Proteomic analysis of cholangiocarcinoma cell line. Proteomics. 2004 Apr;4(4):1135-44. doi: 10.1002/pmic.200300651.
21. Champattanachai V, Ketudat Cairns JR, Shotelersuk V, Keeratichamroen S, Sawangareetrakul P, Srisomsap C, Kaewpaluek V, Svasti J. Novel mutations in a Thai patient with methylmalonic acidemia. Mol Genet Metab. 2003 Aug;79(4):300-2. doi: 10.1016/s1096-7192(03)00106-9.
22. Sawangareetrakul P, Svasti S, Yodsowon B, Winichagoon P, Srisomsap C, Svasti J, Fucharoen S. Double heterozygosity for Hb Pyrgos [beta83(EF7)Gly–>Asp] and Hb E [beta26(B8)Glu–>Lys] found in association with alpha-thalassemia. Hemoglobin. 2002 May;26(2):191-6. doi: 10.1081/hem-120005459.
23. Svasti J, Wasant P, Tiensuwan M, Sawangareetrakul P, Srisomsap C, Pangkanon S, Boonpuan K, Liammongkolkul S. Normal plasma free amino acid levels in Thai children. J Med Assoc Thai. 2001 Nov;84(11):1558-68.
24. Svasti S, Yodsowon B, Sriphanich R, Winichagoon P, Boonkhan P, Suwanban T, Sawangareetrakul P, Srisomsap C, Ketudat-Cairns JR, Svasti J, Fucharoen S. Association of Hb Hope [beta136(H14)Gly–>Asp] and Hb H disease. Hemoglobin. 2001 Nov;25(4):429-35. doi: 10.1081/hem-100107882.
25. Srisomsap C, Svasti J, Surarit R, Champattanachai V, Sawangareetrakul P, Boonpuan K, Subhasitanont P, Chokchaichamnankit D. Isolation and characterization of an enzyme with beta-glucosidase and beta-fucosidase activities from Dalbergia cochinchinensis Pierre. J Biochem. 1996
Mar;119(3):585-90. doi: 10.1093/oxfordjournals.jbchem.a021282.