Dr. Kriengsak Lirdprapamongkol

Name: Dr. Kriengsak Lirdprapamongkol 

Office address: Laboratory of Biochemistry, 7th floor, Biomedical Science Building Chulabhorn Research Institute,
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, ThailandTel: +66 25530 8555 (ext. 8356 )
Mobile: +66-86-986-4485
Fax: +66-2-553-8572
E-mail: kriengsak

Research Scientist II

Research Interests
Cancer biology, Metastasis, Drug resistance, Hypoxia, Apoptosis, Cell signaling, Drug discovery, Photodynamic therapy, Sonodynamic therapy, Natural products

– B.Sc. (Biotechnology), King Mongkut’s Institute of Technology Ladkrabang, THAILAND
– M.Sc. (Biochemistry), Mahidol University, THAILAND
– Ph.D. (Biochemistry), Mahidol University, THAILAND


1. Lirdprapamongkol K, Svasti J. Alkyl glucoside synthesis using Thai rosewood β-glucosidase. Biotechnol Lett. 2000;22(23):1889-94.

2. Lirdprapamongkol K, Mahidol C, Thongnest S, Prawat H, Ruchirawat S, Srisomsap C, et al. Anti-metastatic effects of aqueous extract of Helixanthera parasitica. J Ethnopharmacol. 2003;86(2-3):253-6.

3. Srisomsap C, Sawangareetrakul P, Subhasitanont P, Panichakul T, Keeratichamroen S, Lirdprapamongkol K, et al. Proteomic analysis of cholangiocarcinoma cell line. Proteomics. 2004;4(4):1135-44.

4. Ketudat Cairns JR, Keeratichamroen S, Sukcharoen S, Champattanachai V, Ngiwsara L, Lirdprapamongkol K, et al. The molecular basis of mucopolysaccharidosis type I in two Thai patients. Southeast Asian J Trop Med Public Health. 2005;36(5):1308-12.

5. Lirdprapamongkol K, Sakurai H, Kawasaki N, Choo MK, Saitoh Y, Aozuka Y, et al. Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci. 2005;25(1):57-65.

6. Lirdprapamongkol K, Kramb JP, Chokchaichamnankit D, Srisomsap C, Surarit R, Sila-Asna M, et al. Juice of eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo. In Vivo. 2008;22(3):363-8.

7. Lirdprapamongkol K, Kramb JP, Suthiphongchai T, Surarit R, Srisomsap C, Dannhardt G, et al. Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo. J Agric Food Chem. 2009;57(8):3055-63.

8. Lirdprapamongkol K, Sakurai H, Suzuki S, Koizumi K, Prangsaengtong O, Viriyaroj A, et al. Vanillin Enhances TRAIL-Induced Apoptosis in Cancer Cells through Inhibition of NF-kappa B Activation. In Vivo. 2010;24(4):501-6.

9. Soisuwan S, Warisnoicharoen W, Lirdprapamongkol K, Svasti J. Eco-friendly synthesis of fucoidan-stabilized gold nanoparticles. Amer J Appl Sci. 2010;7:1038-42.

10. Pruksakorn D, Lirdprapamongkol K, Chokchaichamnankit D, Subhasitanont P, Chiablaem K, Svasti J, et al. Metabolic alteration of HepG2 in scaffold-based 3-D culture: Proteomic approach. Proteomics. 2010;10(21):3896-904.

11. Suwannateep N, Banlunara W, Wanichwecharungruang SP, Chiablaem K, Lirdprapamongkol K, Svasti J. Mucoadhesive curcumin nanospheres: Biological activity, adhesion to stomach mucosa and release of curcumin into the circulation. J Control Release. 2011;151(2):176-82.

12. Amornwachirabodee K, Chiablaem K, Wacharasindhu S, Lirdprapamongkol K, Svasti J, Vchirawongkwin V, et al. Paclitaxel delivery using carrier made from curcumin derivative: synergism between carrier and the loaded drug for effective cancer treatment. J Pharm Sci. 2012;101(10):3779-86.

13. Kaewpiboon C, Lirdprapamongkol K, Srisomsap C, Winayanuwattikun P, Yongvanich T, Puwaprisirisan P, et al. Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants. BMC Complement Altern Med. 2012;12:217.

14. Lirdprapamongkol K, Chiablaem K, Sila-Asna M, Surarit R, Bunyaratvej A, Svasti J. Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2012;422(3):429-35.

15. Sakulterdkiat T, Srisomsap C, Udomsangpetch R, Svasti J, Lirdprapamongkol K. Curcumin resistance induced by hypoxia in HepG2 cells is mediated by multidrug-resistance-associated proteins. Anticancer Res. 2012;32(12):5337-42.

16. Khongmanee A, Lirdprapamongkol K, Tit-Oon P, Chokchaichamnankit D, Svasti J, Srisomsap C. Proteomic analysis reveals important role of 14-3-3sigma in anoikis resistance of cholangiocarcinoma cells. Proteomics. 2013;13(21):3157-66.

17. Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Athikomkulchai S, Viriyaroj A, et al. Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol. 2013;43(1):329-37.

18. Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S, et al. A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep. 2013;30(5):2357-64.

19. Pansanit A, Park EJ, Kondratyuk TP, Pezzuto JM, Lirdprapamongkol K, Kittakoop P. Vermelhotin, an Anti-inflammatory agent, suppresses nitric oxide production in RAW 264.7 Cells via p38 Inhibition. J Nat Prod. 2013;76(9):1824-7.

20. Chiablaem K, Lirdprapamongkol K, Keeratichamroen S, Surarit R, Svasti J. Curcumin suppresses vasculogenic mimicry capacity of hepatocellular carcinoma cells through STAT3 and PI3K/AKT inhibition. Anticancer Res. 2014;34(4):1857-64.

21. Chittasupho C, Lirdprapamongkol K, Kewsuwan P, Sarisuta N. Targeted delivery of doxorubicin to A549 lung cancer cells by CXCR4 antagonist conjugated PLGA nanoparticles. Eur J Pharm Biopharm. 2014;88(2):529-38.

22. Raungrut P, Wongkotsila A, Lirdprapamongkol K, Svasti J, Geater SL, Phukaoloun M, et al. Prognostic significance of 14-3-3gamma overexpression in advanced non-small cell lung cancer. Asian Pac J Cancer Prev. 2014;15(8):3513-8.

23. Atjanasuppat K, Lirdprapamongkol K, Jantaree P, Svasti J. Non-adherent culture induces paclitaxel resistance in H460 lung cancer cells via ERK-mediated up-regulation of betaIVa-tubulin. Biochem Biophys Res Commun. 2015;466(3):493-8.

24. Buahorm S, Puthong S, Palaga T, Lirdprapamongkol K, Phuwapraisirisan P, Svasti J, et al. Cardanol isolated from Thai Apis mellifera propolis induces cell cycle arrest and apoptosis of BT-474 breast cancer cells via p21 upregulation. Daru. 2015;23:55.

25. Chaiyawat P, Chokchaichamnankit D, Lirdprapamongkol K, Srisomsap C, Svasti J, Champattanachai V. Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells. Oncol Rep. 2015;34(4):1933-42.

26. Ngokpol S, Suwakulsiri W, Sureram S, Lirdprapamongkol K, Aree T, Wiyakrutta S, et al. Drimane sesquiterpene-conjugated amino acids from a marine isolate of the fungus Talaromyces minioluteus (Penicillium Minioluteum). Mar Drugs. 2015;13(6):3567-80.

27. Pramual S, Assavanig A, Bergkvist M, Batt CA, Sunintaboon P, Lirdprapamongkol K, et al. Development and characterization of bio-derived polyhydroxyalkanoate nanoparticles as a delivery system for hydrophobic photodynamic therapy agents. J Mater Sci Mater Med. 2016;27(2):40.

28. Rukkijakan T, Ngiwsara L, Lirdprapamongkol K, Svasti J, Phetrak N, Chuawong P. A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells. Bioorg Med Chem Lett. 2016;26(9):2119-23.

29. Seemork J, Sansureerungsikul T, Sathornsantikun K, Sinthusake T, Shigyou K, Tree-Udom T, Jiangchareon B, Chiablaem K, Lirdprapamongkol K, et al. Penetration of oxidized carbon nanospheres through lipid bilayer membrane: comparison to graphene oxide and oxidized carbon nanotubes, and effects of ph and membrane composition. ACS Appl Mater Interfaces. 2016;8(36):23549-57.

30. Jantaree P, Lirdprapamongkol K, Kaewsri W, Thongsornkleeb C, Choowongkomon K, Atjanasuppat K, Ruchirawat S, Svasti J. Homodimers of vanillin and apocynin decrease the metastatic potential of human cancer cells by inhibiting the FAK/PI3K/Akt signaling pathway. J Agric Food Chem. 2017;65(11):2299-306.

31. Nooeaid P, Chuysinuan P, Techasakul S, Lirdprapamongkol K, Svasti J. Physico-chemical and in vitro cytotoxic properties of alginate/soy protein isolated scaffolds for tissue engineering. Key Eng Mater. 2017;757:46-51.

32. Kustiawan PM, Lirdprapamongkol K, Palaga T, Puthong S, Phuwapraisirisan P, Svasti J, et al. Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line. BMC Pharmacol Toxicol. 2017;18(1):32.

33. Pramual S, Lirdprapamongkol K, Svasti J, Bergkvist M, Jouan-Hureaux V, Arnoux P, et al. Polymer-lipid-PEG hybrid nanoparticles as photosensitizer carrier for photodynamic therapy. J Photochem Photobiol B. 2017;173:12-22.

34. Wongkanya R, Chuysinuan P, Pengsuk C, Techasakul S, Lirdprapamongkol K, Svasti J, et al. Electrospinning of alginate/soy protein isolated nanofibers and their release characteristics for biomedical applications. J Sci. 2017;2(3):309-16.

35. Subhasitanont P, Chokchaichamnankit D, Chiablaem K, Keeratichamroen S, Ngiwsara L, Paricharttanakul NM, Lirdprapamongkol K, Weeraphan C, Svasti J, Srisomsap C. Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells. Oncol Lett. 2017;14:4361-71.

36. Ketudat Cairns JR, Champattanachai V, Srisomsap C, Paricharttanakul NM, Verathamjamras C, Lirdprapamongkol K, et al. Conference report: the 5th Asia Pacific Protein Association Conference joint meeting with the 12th International Symposium of the Protein Society of Thailand. Biophys Rev. 2017;9(6):857-60.

37. Bissanum R, Lirdprapamongkol K, Svasti J, Navakanitworakul R, Kanokwiroon K. The role of WT1 isoforms in vasculogenic mimicry and metastatic potential of human triple negative breast cancer cells. Biochem Biophys Res Commun. 2017;494(1-2):256-62.

38. Keeratichamroen S, Lirdprapamongkol K, Svasti J. Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells. Oncol Rep. 2018;39(4):1765-74.

39. Samutprasert P, Chiablaem K, Teeraseranee C, Phaiyarin P, Pukfukdee P, Pienpinijtham P, Svasti J, Palaga T, Lirdprapamongkol K, Wanichwecharungruang S. Epigallocatechin gallate-zinc oxide co-crystalline nanoparticles as an anticancer drug that is non-toxic to normal cells. Rsc Adv. 2018;8(14):7369-76.

40. Singhirunnusorn P, Moolmuang B, Lirdprapamongkol K, Ruchirawat M. Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species. J Toxicol Sci. 2018;43(2):159-69.

41. Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Ngiwsara L, Svasti J, Koizumi K. Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-kappaB/VCAM-1 pathway in human lymphatic endothelial cells. Vasc Med. 2018;23(3):201-11.

42. Raungrut P, Wongkotsila A, Champoochana N, Lirdprapamongkol K, Svasti J, Thongsuksai P. Knockdown of 14-3-3gamma Suppresses Epithelial-Mesenchymal Transition and Reduces Metastatic Potential of Human Non-small Cell Lung Cancer Cells. Anticancer Res. 2018;38(6):3507-14.

43. Kuljittichanok D, Diskul-Na-Ayudthaya P, Weeraphan C, Chokchaichamnankit D, Chiablaem K, Lirdprapamongkol K, et al. Effect of Derris scandens extract on a human hepatocellular carcinoma cell line. Oncol Lett. 2018;16(2):1943-52.

44. Netsirisawan P, Chaiyawat P, Chokchaichamnankit D, Lirdprapamongkol K, Srisomsap C, Svasti J, et al. Decreasing O-GlcNAcylation affects the malignant transformation of MCF-7 cells via Hsp27 expression and its O-GlcNAc modification. Oncol Rep. 2018;40(4):2193-205.

45. Saharat K, Lirdprapamongkol K, Chokchaichamnankit D, Srisomsap C, Svasti J, Paricharttanakul NM. Tumor Susceptibility Gene 101 Mediates Anoikis Resistance of Metastatic Thyroid Cancer Cells. Cancer Genomics Proteomics. 2018;15(6):473-83.

46. Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Svasti J, Koizumi K. Shikonin Suppresses Lymphangiogenesis via NF-kappaB/HIF-1alpha Axis Inhibition. Biol Pharm Bull. 2018;41(11):1659-66.

47. Pruksakorn D, Klangjorhor J, Lirdprapamongkol K, Teeyakasem P, Sungngam P, Chaiyawat P, et al. Oncogenic roles of serine-threonine kinase receptor-associated protein (STRAP) in osteosarcoma. Cancer Chemother Pharmacol. 2018;82(6):1039-47.

1. Lirdprapamongkol K, Svasti J, Sakurai H, Saiki I. Anticancer effects of vanillin. In: Preedy V, editor. Beer in health and disease prevention. Academic Press; 2009. p. 260-270.


Leave a Reply

Your email address will not be published. Required fields are marked *