Dr. Chantragan Srisomsap Phiphobmongkol


chantragan
Name: Dr. Chantragan Srisomsap Phiphobmongkol

Office address: Laboratory of Biochemistry, Chulabhorn Research Institute,
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, ThailandTel: +66 25530 8555 (ext. 8360 )

E-mail: chantragan

Research Scientist II

Research Interests
Cancer proteomics research including biomarkers and anticancer drugs treatment on cancer cell lines. Protein and enzyme changes in relation to human cancer, genetic diseases including abnormal hemoglobins and inborn errors of metabolism; carbohydrate- modifying enzymes. Plant proteomics. Biological impacts of pesticides.

Education
1978 B.Sc. (Chemistry), Kasetsart University, Bangkok
1987 Ph.D. (Biochemistry), Auburn University, Alabama 36830, U.S.A.
1986-1989 Postdoctoral Fellow with 3 publications, Cell Biology and Anatomy
Depart¬ment, University of Alabama at Birmingham, Alabama 35249, U.S.A.

Publications: about 100 papers from year 1986-present
1. Srisomsap C, Sawangareetrakul P, Subhasitanont P, Chokchaichamnankit D, Chiablaem K, Bhudhisawasdi V, Wongkham S, Svasti J. Proteomic Studies of Cholangiocarcinoma and Hepatocellular carcinoma Cell Secretomes. J Biomedicine and Biotechnology, 2010, Article ID 437143, 18 pages.

2. Peng L, Kapp EA, Fenyö D, Kwon MS, Jiang P, Wu S, Jiang Y, Aguilar MI, Ahmed N, Baker MS, Cai Z, Chen YJ, Van Chi P, Chung MC, He F, Len AC, Liao PC, Nakamura K, Ngai SM, Paik YK, Pan TL, Poon TC, Hosseini Salekdeh G, Simpson RJ, Sirdeshmukh R, Srisomsap C, Svasti J, Tyan YC, Dreyer FS, McLauchlan D, Rawson P, Jordan TW. The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterisation of the carbonate-washed membrane standard. Proteomics. 2010 Nov;10(22):4142-8.

3. Dumnoensun Pruksakorn, Kriengsak Lirdprapamongkol, Daranee Chokchaichamnankit, Pantipa Subhasitanont, Khajeelak Chiablaem, Jisnuson Svasti, Chantragan Srisomsap. Metabolic alteration of HepG2 in scaffold-based 3-D culture: Proteomic approach. Proteomics, 2010, Nov;10(21):3896-904.

4. Banjerdpongchai R, Kongtawelert P, Khantamat O, Srisomsap C, Chokchaichamnankit D, Subhasitanont P, Svasti J. Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells. J Hematol Oncol. 2010 Dec 30;3:50.

5. Apaporn Boonmee, Chantragan Srisomsap, Aphichart Karnchanatat and Polkit Sangvanich. An antioxidant protein in Curcuma comosa Roxb. Rhizomes. Food Chemistry, 2011, 124, Issue 2, 476-480 .

6. Zuraifah Asrah Mohamad, Daranee Chokchaichamnankit, Kisana Bhinja, N. Monique Paricharttanakul, Jisnuson Svasti, Pattana Srifah Huehne, Chantragan Srisomsap. Proteomic analysis of Chinese kale (B. alboglabra) leaves during growth. Journal of Integrated-Omics., Volume1, Issue 1, February 2011, 102-107.

7. Thongwatchara P, Promwikorn W, Srisomsap C, Chokchaichamnankit D, Boonyaphiphat P, Thongsuksai P. Differential protein expression in primary breast cancer and matched axillary node metastasis. Oncol Rep. 2011 Jul;26(1):185-91. doi: 10.3892/or.2011.1266. Epub 2011 Apr 15.

8. Chatchai Thetsrimuang, Saranyu Khammuang, Khajeelak Chiablaem, Chantragan Srisomsap and Rakrudee Sarnthima. Antioxidant properties and cytotoxicity of crude polysaccharidesfrom Lentinus polychrous Lév. Food Chemistry, Volume 128, Issue 3, 1 October 2011, Pages 634-639.

9. Apaporn Boonmee, Chantragan Srisomsap, Daranee Chokchaichamnankit, Aphichart Karnchanatat and Polkit Sangvanich . A proteomic analysis of Curcuma comosa Roxb. Rhizomes. Proteome Science 2011, 9:43 doi:10.1186/1477-5956-9-43.

10. Amporn Leecharoenkiat, Tirawat Wannatung, Pathrapol Lithanatudom, Saovaros Svasti, Suthat Fucharoen, Daranee Chokchaichamnankit, Chantragan Srisomsap, Duncan R Smith. Increased oxidative metabolism is associated with erythroid precursor expansion in β(0)-thalassaemia/Hb E disease. Blood cells, Molecules & Diseases. 07/2011.

11. Sukanya Sriiam, Amporn Leecharoenkiat, Pathrapol Lithanatudom, Tirawat Wannatung, Saovaros Svasti, Suthat Fucharoen, Jisnuson Svasti, Daranee Chokchaichamnankit, Chantragan Srisomsap, Duncan R. Smith. Proteomic analysis of Hemoglobin H-Constant Spring (Hb H-CS) erythroblasts. Blood Cells, Molecules, and Diseases.7 December 2011.

12. Apaporn Boonmee, Chantragan Srisomsap, Aphichart Karnchanatat and Polkit Sangvanich. Biologically active proteins from Curcuma comosa Roxb. Rhizomes. Journal of Medicinal Plants Research Vol. 5(21), pp. 5208-5215, 9 October, 2011.

13. Suksalak, W., Paricharttanakul, N. M., Svasti, J and Srisomsap C. (2011) Screening of Thai Traditional Medicinal Plant Extracts as Potential Anticancer Agents. Proceedings in the 3rd Biochemistry and Molecular Biology Conference (BMB), Chiangmai, April 6-8, 2011, pp 214-8.

14. Chanchai Sukkum, Daranee Chackchaichamnankit, Khajeelak Chiablaem, Penchatr Diskul Na Ayudthaya, Jisnuson Svasti, Chantragan Srisomsap. Characterization of HepG2 cells upon atrazine exposure. Proceedings in the Center of Excellence on Environmental Health, Toxicology and Management of Chemical, Perspectives in Environmental Health Research, Chulabhorn convention center, Bangkok, August 21, 2011.

15. Thongtan T, Wikan N, Wintachai P, Rattanarungsan C, Srisomsap C, Cheepsunthorn P, Smith DR. Characterization of putative Japanese encephalitis virus receptor molecules on microglial cells. J Med Virol. 2012 Apr;84(4):615-23. doi: 10.1002/jmv.23248

16. Churat Weeraphan, Chantragan Srisomsap, Daranee Chokchaichamnankit, Pantipa Subhasitanont, Suneerat Hatairaktham, Ratiya Charoensakdi, Narumol Panichkul, Noppadol Siritanaratkul, Suthat Fucharoen, Jisnuson Svasti, Ruchaneekorn W. Kalpravidh. Role of Curcuminoids in Ameliorating Oxidative Modification in -thalassemia/Hb E Plasma Proteome Journal of Nutritional Biochemistry, 2012 Jul 18.

17. Sakulterdkiat T, Srisomsap C, Udomsangpetch R, Svasti J, Lirdprapamongkol K. Curcumin resistance induced by hypoxia in HepG2 cells is mediated by multidrug-resistance-associated proteins. Anticancer Res. Anticancer Res. 2012 Dec;32(12):5337-42.

18. Weeraphan C, Diskul-Na-Ayudthaya P, Chiablaem K, Khongmanee A, Chokchaichamnankit D, Subhasitanont P, Svasti J, Srisomsap C. Effective enrichment of cholangiocarcinoma secretomes using the hollow fiber bioreactor culture system. Talanta, 2012 Sep 15;99:294-301. doi: 10.1016/j.talanta.2012.05.054. Epub 2012 Jun 16.

19. Vatanavicharn N, Champattanachai V, Liammongkolkul S, Sawangareetrakul P, Keeratichamroen S, Ketudat Cairns JR, Srisomsap C, Sathienkijkanchai A, Shotelersuk V, Kamolsilp M. Wattanasirichaigoon D, Svasti J, Wasant P. Clinical and molecular findings in Thai patients with isolated methylmalonic acidemia. Mol Genet Metab. 2012 Aug;106(4):424-9. [Epub 2012 May 29]

20. Chaisanit C., Srisomsap C., Panriansaen R. and Cherdshewasart W. Cytotoxicity of the Rejuvenating Thai Herbal Plants Against Prostate Cancer Cells. Proceeding the 50th Kasetsart University Annual Conference, Kasetsart University, Bangkok, Thailand. 31 Jan – 2 Feb 2012.

21. Chaiwalitpong S., Srisomsap C., Panriansaen R. and Cherdshewasart W. Cytotoxic Against MDA-MB-213 Breast Cancer Cells by the Rejuvenating Thai Herbal Plants. Proceeding the 50th Kasetsart University Annual Conference, Kasetsart University, Bangkok, Thailand. 31 Jan – 2 Feb 2012.

22. Topan K., Srisomsap C., Panriansaen R. and Cherdshewasart W. Cytotoxic Against Lung Cancer Cells (CHAGO) by the Thai Rejuvenating Herbal Plants. Proceeding the 50th Kasetsart University Annual Conference, Kasetsart University, Bangkok, Thailand. 31 Jan – 2 Feb 2012.

23. Kaewpiboon C, Lirdprapamongkol K, Srisomsap C, Winayanuwattikun P, Yongvanich T, Puwaprisirisan P, Svasti J, Assavalapsakul W. Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants. BMC Complement Altern Med. 2012 Nov 13;12:217. doi: 10.1186/1472-6882-12-217.

24. Champattanachai V, Netsirisawan P, Chaiyawat P, Phueaouan T, Charoenwattanasatien R, Chokchaichamnankit D, Punyarit P, Srisomsap C, Svasti J. Proteomic analysis and abrogated expression of O-GlcNAcylated proteins associated with primary breast cancer. Proteomics. 2013 Apr 11. doi: 10.1002/pmic.201200126. [Epub ahead of print]

25. Zuraifah Asrah Mohamad, Daranee Chokchaichamnankit, Kisana Bhinija, N. Monique Paricharttanakul, Jisnuson Svasti, Pattana Srifah Huehne and Chantragan Srisomsap. Proteome level changes in the root of Brassica alboglabra induced by alachlor herbicide. African Journal of Biotechnology. pp. 2840-2849DOI: 10.5897/AJB12.2070

26. Pitak Chanthammachata, Waraporn Promwikorna, Kowit Pruegsanusakb, Sittiruk Roytrakulc, Chantragan Srisomsap, Daranee Chokchaichamnankitd, Jisnuson Svasti, Pleumjit Boonyaphiphate, Singkhamanan Kf, Paramee Thongsuksaie, Comparative proteomic analysis of oral squamous cell carcinoma and adjacent non-tumour tissue from Thailand. Archives of Oral Biology, 2013, 58, 11, 1677–1685.

27. Amnart Khongmanee, Kriengsak Lirdprapamongkol, Phanthakarn Tit-oon, Daranee Chokchaichamnankit, Jisnuson Svasti, Chantragan Srisomsap. Proteomic analysis reveals important role of 14–3–3σ in anoikis resistance of cholangiocarcinoma cells. Proteomics 2013ใ

28. Phueaouan T, Chaiyawat P, Netsirisawan P, Chokchaichamnankit D, Punyarit P, Srisomsap C, Svasti J, Champattanachai V. Aberrant O-GlcNAc-modified proteins expressed in primary colorectal cancer. Oncol Rep. 2013, 30(6):2929-36.

29. Niyomploy P, Srisomsap C, Chokchaichamnankit D, Vinayavekhin N, Karnchanatat A, Sangvanich P. Superoxide dismutase isozyme detection using two-dimensional gel electrophoresis zymograms. J Pharm Biomed Anal. 2014, 90:72-77.

30. Khanaruksombat S, Srisomsap C, Chokchaichamnankit D, Punyarit P, Phiriyangkul P. Identification of a novel allergen from muscle and various organs in banana shrimp (Fenneropenaeus merguiensis). Ann Allergy Asthma Immunol. 2014, 113(3):301-6.

31. Tit-Oon P, Chokchaichamnankit D, Khongmanee A, Sawangareetrakul P, Svasti J, Srisomsap C. Comparative secretome analysis of cholangiocarcinoma cell line in three-dimensional culture. Int J Oncol. 2014 Sep 3. doi: 10.3892/ijo.2014.2636. [Epub ahead of print]

32. Thongpoo P, Srisomsap C,Chokchaichamnankit D, Kitpreechavanich V, Svasti J, Kongsaeree PT. Purification and characterization of three β-glycosidases exhibiting high glucose tolerance from Aspergillusniger ASKU28.BiosciBiotechnolBiochem. 2014 Jul;78(7):1167-76. doi: 10.1080/09168451.2014.915727. Epub 2014 May 28.

33.Srinroch C, Srisomsap C, Chokchaichamnankit D, Punyarit P, Phiriyangkul P. Identification of novel allergen in edible insect, Gryllusbimaculatus and its cross-reactivity with Macrobrachium spp. allergens. Food Chem. 2015 Oct 1;184:160-6. doi: 10.1016/j.foodchem.2015.03.094. Epub 2015 Mar 28.

34.HifzaBaig, PenchatrDiskul-Na-Ayudthaya, ChuratWeeraphan, N. Monique Paricharttanakul, JisnusonSvasti, ChantraganSrisomsap. Inhibitory effect of BrideliaovataDecne extract on HepG2 cell migration and invasion stimulated by fibroblast-conditioned media.NaresuanPhayao J. 2015;8(1):6-10.

35.Chutipongtanate S, Changtong C, Weeraphan C, Hongeng S, Srisomsap C and Svasti J . Syringe-push membrane absorption as a simple rapid method of urine preparation for clinical proteomics.Clinical Proteomics2015, 12:15.doi:10.1186/s12014-015-9087-4.

36.Netsirisawan P, Chokchaichamnankit D, Srisomsap C,Svasti J and Chanpattanachai V. Proteomic Analysis Reveals Aberrant O-GlcNAcylation of Extracellular Proteins from Breast Cancer Cell Secretion.Cancer Genomics and Proteomics 2015, 12, 4, 201-209.

37.ParunyaChaiyawat, DaraneeChokchaichamnankit, KriengsakLirdprapamongkol ,ChantraganSrisomsap,JisnusonSvasti and VorarattChampattanachai. Alteration of O-GlcNAcylation affects serine phosphorylationand regulates gene expression and activity of pyruvatekinase M2 in colorectal cancer cells2015, 1933-1942.

38.Hua Y, Ekkhara W, Sansenya S, Srisomsap C, Roytrakul S, Saburi W, Takeda R, Matsuura H, Mori H, Ketudat Cairns JR. Identification of rice Os4BGlu13 as a β-glucosidase which hydrolyzes gibberellin A4 1-O-β-d-glucosyl ester, in addition to tuberonic acid glucoside and salicylic acid derivative glucosides.Arch BiochemBiophys. 2015 Aug 1;583:36-46.

39.KitisakSintiprungrat, KamolwanWatcharatanyatip, W.D.S.T. Senevirathne, PapadaChaisuriya, DaraneeChokchaichamnankit, ChantraganSrisomsap, KaviRatanabanangkoon. A comparative study of venomics of Najanaja from India and Sri Lanka, clinical manifestations and antivenomics of an Indianpolyspecificantivenom.J Proteomics.2015 Oct 23.pii: S1874-3919(15)30152-4. doi: 10.1016/j.jprot.2015.10.007. [Epub ahead of print]

40. PharimaPhiriyangkul, ChutimaSrinroch, ChantraganSrisomsap, DaraneeChokchaichamnankit and PhaibulPunyarit.Effect of Food Thermal Processing on Allergenicity Proteins in Bombay Locust (PatangaSuccincta). International Journal of Food Engineering Vol. 1, No. 1, June 2015.

41.Jungsukcharoen J, Chokchaichamnankit D, Srisomsap C, Cherdshewasart W, Sangvanich P. Proteome analysis of Puerariamirifica tubers collected in different seasons. BiosciBiotechnolBiochem. 2016 Jun;80(6):1070-80. doi: 10.1080/09168451.2016.1141035. Epub 2016 Mar 4.

42.Buncherd H, Roseboom W, Chokchaichamnankit D, Sawangareetrakul P, Phongdara A, Srisomsap C, de Jong L, Svasti J.β-Elimination coupled with strong cation-exchange chromatography for phosphopeptide analysis. Rapid Commun Mass Spectrom. 2016 Jul 30;30(14):1695-1704. doi: 10.1002/rcm.7606.

43.Paricharttanakul NM, Saharat K, Chokchaichamnankit D, Punyarit P, Srisomsap C, SvastiJ.Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas.Oncol Rep. 2016 Apr;35(4):2286-96. doi: 10.3892/or.2016.4567. Epub 2016 Jan 15.

44.Leelahawong C, Srisomsap C, Cherdshewasart W, Chokchaichamnankit D, Vinayavekhin N, Sangvanich P. Comparative protein profiles of Buteasuperba tubers under seasonal changes.MolBiol Rep. 2016 Jul;43(7):719-36. doi: 10.1007/s11033-016-4010-2. Epub 2016 May 19.

45.Pruksakorn D., Teeyakasem P., Klangjorhor J., Chaiyawat P., Settakorn J., Diskul-Na- Ayudthaya P, Chokchaichamnankit D., Pothacharoen P. and Srisomsap C.Overexpression of KH-type splicing regulatory protein regulates proliferation, migration, and implantation ability of osteosarcoma. International Journal of Oncology (2016). (online)

46.Khondee P, Srisomsap C, Chokchaichamnankit D,  Svasti J, Simpson RJ, Kingtong S.Histopathological effect and stress response of mantle proteome following TBT exposure in the Hooded oyster Saccostreacucullata. Environ Pollut. 2016 Aug 9.pii: S0269-7491(16)30688-1. doi: 10.1016/j.envpol.2016.08.011. [Epub ahead of print]

47. Ruangjaroon T, Chokchaichamnankit D, Srisomsap C, Svasti J, Paricharttanakul NM.Involvement of vimentin in neurite outgrowth damage induced by fipronil in SH-SY5Y cells.BiochemBiophys Res Commun.2017 May 6;486(3):652-658. doi: 10.1016/j.bbrc.2017.03.081. Epub 2017 Mar 18.

48.Verathamjamras C, Weeraphan C,  Chokchaichamnankit D, Watcharatanyatip K,  PantipaSubhasitanont, PenchatrDiskul-Na-Ayudthaya, Mingkwan K, Luevisadpaibul V, Chutipongtanates S, Champattanachai V, Svasti J, and. Srisomsap C. Secretomic profiling of cells from hollow fiber bioreactor reveals PSMA3 as a potential cholangiocarcinoma biomarker. International Journal of Oncology.Jul;51(1):269-280. doi: 10.3892/ijo.2017.4024. Epub 2017 May 29.

49.Subhasitanont P, Chokchaichamnankit D, Chiablaem K,  Keeratichamroen S, Ngiwsara L, Paricharttanakul NM, Lirdprapamongkol K, Weeraphan C, Svasti J, Srisomsap C.Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells.OncolLett. 2017 Oct;14(4):4361-4371. doi: 10.3892/ol.2017.6705. Epub 2017 Aug 2.

50.Ketudat Cairns JR, Champattanachai V, Srisomsap C, Paricharttanakul NM, Verathamjamras C, Lirdprapamongkol K, Svasti J. Conference report: the 5th Asia Pacific Protein Association Conference joint meeting with the 12th International Symposium of the Protein Society of Thailand.Biophys Rev. 2017 Dec;9(6):857-860. doi: 10.1007/s12551-017-0318-y. Epub 2017 Sep 7.

51.Chatchen S, Pongsakul N, Srisomsap C, Chiangjong W, Hongeng S, Svasti J, Chutipongtanate S.Unravelling Pathophysiology of Crystalline Nephropathy in Ceftriaxone-Associated Acute Kidney Injury: A Cellular Proteomic Approach.Nephron. 2018 Jan 16.doi: 10.1159/000486324. [Epub ahead of print]

52.Kuljittichanok D., Diskul-Na-Ayudthaya P., Weeraphan C., Chokchaichamnankit D., Chiablaem K., Lirdprapamongkol K., Svasti J. and Srisomsap C. Effects of Derris scandens extract on human hepatocellular carcinoma cell line. Oncology Lett. 2018 May 29:1943-1952.doi.org/10.3892/ol.2018.8824

53.Arthornthurasuk S, Jenkhetkan W, Suwan E, Chokchaichamnankit D, Srisomsap C, Wattana-Amorn P, Svasti J, Kongsaeree PT.Molecular Characterization and Potential Synthetic Applications of GH1 β-Glucosidase from Higher Termite Microcerotermesannandalei.ApplBiochemBiotechnol. 2018 Dec;186(4):877-894. doi: 10.1007/s12010-018-2781-8. Epub 2018 May 19.

54.Pruksakorn D, Klangjorhor J, Lirdprapamongkol K, Teeyakasem P, Sungngam P, Chaiyawat P, Phanphaisarn A, Settakorn J, Srisomsap C, Oncogenic roles of serine-threonine kinase receptor-associated protein (STRAP) in osteosarcoma. Cancer ChemotherPharmacol. 2018 Dec;82(6):1039-1047. doi: 10.1007/s00280-018-3696-3. Epub 2018 Oct 1.

55.Saharat K, Lirdprapamongkol K, Chokchaichamnankit D, Srisomsap C, Svasti J, Paricharttanakul NM. Tumor Susceptibility Gene 101 Mediates Anoikis Resistance of Metastatic Thyroid Cancer Cells.Cancer Genomics Proteomics. 2018 Nov-Dec;15(6):473-483. doi: 10.21873/cgp.20106.

56.Chaiyawat P, Sungngam P, Teeyakasem P, Sirikaew N, Klangjorhor J, Settakorn J, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Srisomsap C, Svasti J, Pruksakorn D. Protein profiling of osteosarcoma tissue and soft callus unveils activation of the unfolded protein response pathway. Int J Oncol. 2019 Feb 28.doi: 10.3892/ijo.2019.4737. [Epub ahead of print]

57. Panachan J, Chokchaichamnankit D, Weeraphan C, Srisomsap C, Masaratana P, Hatairaktham S, Panichkul N, Svasti J, Kalpravidh RW.Differentially expressed plasma proteins of β-thalassemia/hemoglobin E patients in response to curcuminoids/vitamin E antioxidant cocktails.Hematology.2019 Jan;24(1):300-307. doi: 10.1080/16078454.2019.1568354.

58. Chokchaichamnankit D, Watcharatanyatip K, Subhasitanont P, Weeraphan C, Keeratichamroen, Narongrit S, Kantathavorn N, Diskul-Na-Ayudthaya P, Saharat K, Chantaraamporn N, Verathamjamras C, Phoolcharoen N, Wiriyaukaradecha K, Paricharttanakul N. M., Udomchaiprasertkul W, Sricharunrat T, Auewarakul C, Svasti J and Srisomsap C.Urinary biomarkers for the diagnosis of cervical cancer by quantitative label‑free mass spectrometry analysis. Oncology Lett.2019: DOI: 10.3892/ol.2019.10227.

 

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